Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides

Inomata et al. isolate zinc-dependent DNAzymes with compact catalytic core sequences displaying highly versatile hydrolysis activity. The cleavable substrate variation for the DNAzymes (ZincDz2 and ZincDz2-v2) is very broad and the authors further demonstrate their utility by showing ZincDz2 can hyd...

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Autores principales:	Rika Inomata, Jing Zhao, Makoto Miyagishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/667af51242b84672bb30a21379eb5f19
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spelling	oai:doaj.org-article:667af51242b84672bb30a21379eb5f192021-12-02T14:03:56ZZn2+-dependent DNAzymes that cleave all combinations of ribonucleotides10.1038/s42003-021-01738-62399-3642https://doaj.org/article/667af51242b84672bb30a21379eb5f192021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01738-6https://doaj.org/toc/2399-3642Inomata et al. isolate zinc-dependent DNAzymes with compact catalytic core sequences displaying highly versatile hydrolysis activity. The cleavable substrate variation for the DNAzymes (ZincDz2 and ZincDz2-v2) is very broad and the authors further demonstrate their utility by showing ZincDz2 can hydrolyze miR-155 in vitro at three different sites. With their broad substrate tolerance, this study advances the DNAzyme field for RNA cleavage applications.Rika InomataJing ZhaoMakoto MiyagishiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Rika Inomata Jing Zhao Makoto Miyagishi Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides
description	Inomata et al. isolate zinc-dependent DNAzymes with compact catalytic core sequences displaying highly versatile hydrolysis activity. The cleavable substrate variation for the DNAzymes (ZincDz2 and ZincDz2-v2) is very broad and the authors further demonstrate their utility by showing ZincDz2 can hydrolyze miR-155 in vitro at three different sites. With their broad substrate tolerance, this study advances the DNAzyme field for RNA cleavage applications.
format	article
author	Rika Inomata Jing Zhao Makoto Miyagishi
author_facet	Rika Inomata Jing Zhao Makoto Miyagishi
author_sort	Rika Inomata
title	Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides
title_short	Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides
title_full	Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides
title_fullStr	Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides
title_full_unstemmed	Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides
title_sort	zn2+-dependent dnazymes that cleave all combinations of ribonucleotides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/667af51242b84672bb30a21379eb5f19
work_keys_str_mv	AT rikainomata zn2dependentdnazymesthatcleaveallcombinationsofribonucleotides AT jingzhao zn2dependentdnazymesthatcleaveallcombinationsofribonucleotides AT makotomiyagishi zn2dependentdnazymesthatcleaveallcombinationsofribonucleotides
_version_	1718392024833458176

Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides

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