Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer

The definition of biomarkers to predict therapy responses to immune-checkpoint inhibitors represent an unmet clinical need. Here the authors provide evidences that platelet-derived PD-L1 could serve as a prognostic and predictive biomarker in patients with non-small cell lung cancer.

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Autores principales:	Clemens Hinterleitner, Jasmin Strähle, Elke Malenke, Martina Hinterleitner, Melanie Henning, Marco Seehawer, Tatjana Bilich, Jonas Heitmann, Martina Lutz, Sven Mattern, Sophia Scheuermann, Marius Horger, Stefanie Maurer, Juliane Walz, Falko Fend, Rupert Handgretinger, Christian Seitz, Bettina Weigelin, Stephan Singer, Helmut Salih, Oliver Borst, Hans-Georg Kopp, Lars Zender
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/667bac11196140cc814118dc5b22f2f3
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spelling	oai:doaj.org-article:667bac11196140cc814118dc5b22f2f32021-12-05T12:22:31ZPlatelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer10.1038/s41467-021-27303-72041-1723https://doaj.org/article/667bac11196140cc814118dc5b22f2f32021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27303-7https://doaj.org/toc/2041-1723The definition of biomarkers to predict therapy responses to immune-checkpoint inhibitors represent an unmet clinical need. Here the authors provide evidences that platelet-derived PD-L1 could serve as a prognostic and predictive biomarker in patients with non-small cell lung cancer.Clemens HinterleitnerJasmin SträhleElke MalenkeMartina HinterleitnerMelanie HenningMarco SeehawerTatjana BilichJonas HeitmannMartina LutzSven MatternSophia ScheuermannMarius HorgerStefanie MaurerJuliane WalzFalko FendRupert HandgretingerChristian SeitzBettina WeigelinStephan SingerHelmut SalihOliver BorstHans-Georg KoppLars ZenderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clemens Hinterleitner Jasmin Strähle Elke Malenke Martina Hinterleitner Melanie Henning Marco Seehawer Tatjana Bilich Jonas Heitmann Martina Lutz Sven Mattern Sophia Scheuermann Marius Horger Stefanie Maurer Juliane Walz Falko Fend Rupert Handgretinger Christian Seitz Bettina Weigelin Stephan Singer Helmut Salih Oliver Borst Hans-Georg Kopp Lars Zender Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
description	The definition of biomarkers to predict therapy responses to immune-checkpoint inhibitors represent an unmet clinical need. Here the authors provide evidences that platelet-derived PD-L1 could serve as a prognostic and predictive biomarker in patients with non-small cell lung cancer.
format	article
author	Clemens Hinterleitner Jasmin Strähle Elke Malenke Martina Hinterleitner Melanie Henning Marco Seehawer Tatjana Bilich Jonas Heitmann Martina Lutz Sven Mattern Sophia Scheuermann Marius Horger Stefanie Maurer Juliane Walz Falko Fend Rupert Handgretinger Christian Seitz Bettina Weigelin Stephan Singer Helmut Salih Oliver Borst Hans-Georg Kopp Lars Zender
author_facet	Clemens Hinterleitner Jasmin Strähle Elke Malenke Martina Hinterleitner Melanie Henning Marco Seehawer Tatjana Bilich Jonas Heitmann Martina Lutz Sven Mattern Sophia Scheuermann Marius Horger Stefanie Maurer Juliane Walz Falko Fend Rupert Handgretinger Christian Seitz Bettina Weigelin Stephan Singer Helmut Salih Oliver Borst Hans-Georg Kopp Lars Zender
author_sort	Clemens Hinterleitner
title	Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
title_short	Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
title_full	Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
title_fullStr	Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
title_full_unstemmed	Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
title_sort	platelet pd-l1 reflects collective intratumoral pd-l1 expression and predicts immunotherapy response in non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/667bac11196140cc814118dc5b22f2f3
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Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer

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