Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study

BackgroundWe aimed to compare the associations of smoking exposure as assessed by self‐reports and urine cotinine with cardiovascular disease (CVD) risk and determine the potential utility of cotinine for CVD risk prediction. Methods and ResultsSmoking status by self‐reports and urine cotinine were...

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Autores principales:	Setor K. Kunutsor, Julia M. Spee, Lyanne M. Kieneker, Ron T. Gansevoort, Robin P. F. Dullaart, Albert‐Jan Voerman, Daan J. Touw, Stephan J. L. Bakker
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	cardiovascular disease cohort study cotinine risk factor risk prediction smoking Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/667c396bb043445f9ee5523832d92289
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spelling	oai:doaj.org-article:667c396bb043445f9ee5523832d922892021-11-12T17:01:53ZSelf‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study10.1161/JAHA.118.0087262047-9980https://doaj.org/article/667c396bb043445f9ee5523832d922892018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.118.008726https://doaj.org/toc/2047-9980BackgroundWe aimed to compare the associations of smoking exposure as assessed by self‐reports and urine cotinine with cardiovascular disease (CVD) risk and determine the potential utility of cotinine for CVD risk prediction. Methods and ResultsSmoking status by self‐reports and urine cotinine were assessed at baseline in 4737 participants (mean age, 53 years) of the PREVEND (Prevention of Renal and Vascular End‐Stage Disease) prospective study. Participants were classified as never, former, light current (≤10 cigarettes/day), and heavy current smokers (>10 cigarettes/day) according to self‐reports and analogous cutoffs for urine cotinine. During a median follow‐up of 8.5 years, 296 first CVD events were recorded. Compared with self‐reported never smokers, the hazard ratios (95% confidence interval) of CVD for former, light current, and heavy current smokers were 0.86 (0.64–1.17), 1.28 (0.83–1.97), and 1.80 (1.27–2.57) in multivariate analysis. Compared with urine cotinine–assessed never smokers, the corresponding hazard ratios of CVD for urine cotinine–assessed former, light current, and heavy current smokers were 1.70 (1.03–2.81), 1.62 (1.15–2.28), and 1.95 (1.39–2.73) respectively. The C‐index change on adding urine cotinine–assessed smoking status to a standard CVD risk prediction model (without self‐reported smoking status) was 0.0098 (0.0031–0.0164; P=0.004). The corresponding C‐index change for self‐reported smoking status was 0.0111 (0.0042–0.0179; P=0.002). ConclusionsSmoking status as assessed by self‐reports and urine cotinine is associated with CVD risk; however, the nature of the association of urine cotinine with CVD is consistent with a dose‐response relationship. The ability of urine cotinine to improve CVD risk assessment is similar to that of self‐reported smoking status.Setor K. KunutsorJulia M. SpeeLyanne M. KienekerRon T. GansevoortRobin P. F. DullaartAlbert‐Jan VoermanDaan J. TouwStephan J. L. BakkerWileyarticlecardiovascular diseasecohort studycotininerisk factorrisk predictionsmokingDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease cohort study cotinine risk factor risk prediction smoking Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cardiovascular disease cohort study cotinine risk factor risk prediction smoking Diseases of the circulatory (Cardiovascular) system RC666-701 Setor K. Kunutsor Julia M. Spee Lyanne M. Kieneker Ron T. Gansevoort Robin P. F. Dullaart Albert‐Jan Voerman Daan J. Touw Stephan J. L. Bakker Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study
description	BackgroundWe aimed to compare the associations of smoking exposure as assessed by self‐reports and urine cotinine with cardiovascular disease (CVD) risk and determine the potential utility of cotinine for CVD risk prediction. Methods and ResultsSmoking status by self‐reports and urine cotinine were assessed at baseline in 4737 participants (mean age, 53 years) of the PREVEND (Prevention of Renal and Vascular End‐Stage Disease) prospective study. Participants were classified as never, former, light current (≤10 cigarettes/day), and heavy current smokers (>10 cigarettes/day) according to self‐reports and analogous cutoffs for urine cotinine. During a median follow‐up of 8.5 years, 296 first CVD events were recorded. Compared with self‐reported never smokers, the hazard ratios (95% confidence interval) of CVD for former, light current, and heavy current smokers were 0.86 (0.64–1.17), 1.28 (0.83–1.97), and 1.80 (1.27–2.57) in multivariate analysis. Compared with urine cotinine–assessed never smokers, the corresponding hazard ratios of CVD for urine cotinine–assessed former, light current, and heavy current smokers were 1.70 (1.03–2.81), 1.62 (1.15–2.28), and 1.95 (1.39–2.73) respectively. The C‐index change on adding urine cotinine–assessed smoking status to a standard CVD risk prediction model (without self‐reported smoking status) was 0.0098 (0.0031–0.0164; P=0.004). The corresponding C‐index change for self‐reported smoking status was 0.0111 (0.0042–0.0179; P=0.002). ConclusionsSmoking status as assessed by self‐reports and urine cotinine is associated with CVD risk; however, the nature of the association of urine cotinine with CVD is consistent with a dose‐response relationship. The ability of urine cotinine to improve CVD risk assessment is similar to that of self‐reported smoking status.
format	article
author	Setor K. Kunutsor Julia M. Spee Lyanne M. Kieneker Ron T. Gansevoort Robin P. F. Dullaart Albert‐Jan Voerman Daan J. Touw Stephan J. L. Bakker
author_facet	Setor K. Kunutsor Julia M. Spee Lyanne M. Kieneker Ron T. Gansevoort Robin P. F. Dullaart Albert‐Jan Voerman Daan J. Touw Stephan J. L. Bakker
author_sort	Setor K. Kunutsor
title	Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study
title_short	Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study
title_full	Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study
title_fullStr	Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study
title_full_unstemmed	Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study
title_sort	self‐reported smoking, urine cotinine, and risk of cardiovascular disease: findings from the <styled-content style="fixed-case">prevend</styled-content> (prevention of renal and vascular end‐stage disease) prospective cohort study
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/667c396bb043445f9ee5523832d92289
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Self‐Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the <styled-content style="fixed-case">PREVEND</styled-content> (Prevention of Renal and Vascular End‐Stage Disease) Prospective Cohort Study

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