Activity-Related Conformational Changes in <sc>d,d</sc>-Carboxypeptidases Revealed by <italic toggle="yes">In Vivo</italic> Periplasmic Förster Resonance Energy Transfer Assay in <italic toggle="yes">Escherichia coli</italic>
ABSTRACT One of the mechanisms of β-lactam antibiotic resistance requires the activity of d,d-carboxypeptidases (d,d-CPases) involved in peptidoglycan (PG) synthesis, making them putative targets for new antibiotic development. The activity of PG-synthesizing enzymes is often correlated with their a...
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| Main Authors: | , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2017
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| Subjects: | |
| Online Access: | https://doaj.org/article/667f6b6d758e4d2bb1bbb84ac97a7682 |
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