Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation

Virulent type III secretion systems (T3SSs) or injectisomes enable pathogenic bacteria to inject effector proteins directly into the host cell cytoplasm. Structures of a needle complex engaged with the effector protein reveal the complete secretion channel and provide insights into the mechanism of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sean Miletic, Dirk Fahrenkamp, Nikolaus Goessweiner-Mohr, Jiri Wald, Maurice Pantel, Oliver Vesper, Vadim Kotov, Thomas C. Marlovits
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66891609afd94b18bb304e7a5fff8d52
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:66891609afd94b18bb304e7a5fff8d52
record_format	dspace
spelling	oai:doaj.org-article:66891609afd94b18bb304e7a5fff8d522021-12-02T13:33:09ZSubstrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation10.1038/s41467-021-21143-12041-1723https://doaj.org/article/66891609afd94b18bb304e7a5fff8d522021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21143-1https://doaj.org/toc/2041-1723Virulent type III secretion systems (T3SSs) or injectisomes enable pathogenic bacteria to inject effector proteins directly into the host cell cytoplasm. Structures of a needle complex engaged with the effector protein reveal the complete secretion channel and provide insights into the mechanism of substrate translocation through T3SSs.Sean MileticDirk FahrenkampNikolaus Goessweiner-MohrJiri WaldMaurice PantelOliver VesperVadim KotovThomas C. MarlovitsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean Miletic Dirk Fahrenkamp Nikolaus Goessweiner-Mohr Jiri Wald Maurice Pantel Oliver Vesper Vadim Kotov Thomas C. Marlovits Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
description	Virulent type III secretion systems (T3SSs) or injectisomes enable pathogenic bacteria to inject effector proteins directly into the host cell cytoplasm. Structures of a needle complex engaged with the effector protein reveal the complete secretion channel and provide insights into the mechanism of substrate translocation through T3SSs.
format	article
author	Sean Miletic Dirk Fahrenkamp Nikolaus Goessweiner-Mohr Jiri Wald Maurice Pantel Oliver Vesper Vadim Kotov Thomas C. Marlovits
author_facet	Sean Miletic Dirk Fahrenkamp Nikolaus Goessweiner-Mohr Jiri Wald Maurice Pantel Oliver Vesper Vadim Kotov Thomas C. Marlovits
author_sort	Sean Miletic
title	Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
title_short	Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
title_full	Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
title_fullStr	Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
title_full_unstemmed	Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
title_sort	substrate-engaged type iii secretion system structures reveal gating mechanism for unfolded protein translocation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66891609afd94b18bb304e7a5fff8d52
work_keys_str_mv	AT seanmiletic substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation AT dirkfahrenkamp substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation AT nikolausgoessweinermohr substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation AT jiriwald substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation AT mauricepantel substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation AT olivervesper substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation AT vadimkotov substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation AT thomascmarlovits substrateengagedtypeiiisecretionsystemstructuresrevealgatingmechanismforunfoldedproteintranslocation
_version_	1718392857039994880

Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation

Ejemplares similares