Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
Virulent type III secretion systems (T3SSs) or injectisomes enable pathogenic bacteria to inject effector proteins directly into the host cell cytoplasm. Structures of a needle complex engaged with the effector protein reveal the complete secretion channel and provide insights into the mechanism of...
Guardado en:
Autores principales: | Sean Miletic, Dirk Fahrenkamp, Nikolaus Goessweiner-Mohr, Jiri Wald, Maurice Pantel, Oliver Vesper, Vadim Kotov, Thomas C. Marlovits |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/66891609afd94b18bb304e7a5fff8d52 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structure of the substrate-engaged SecA-SecY protein translocation machine
por: Chengying Ma, et al.
Publicado: (2019) -
Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism
por: Alexandra J. Machen, et al.
Publicado: (2021) -
Structures of chaperone-substrate complexes docked onto the export gate in a type III secretion system
por: Qiong Xing, et al.
Publicado: (2018) -
The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
por: Lucas Kuhlen, et al.
Publicado: (2020) -
Field effect control of translocation dynamics in surround-gate nanopores
por: Makusu Tsutsui, et al.
Publicado: (2021)