Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.

<h4>Background</h4>Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a...

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Autores principales:	Ti Wang, Zhen Zeng, Tao Li, Jie Liu, Junyan Li, You Li, Qian Zhao, Zhiyun Wei, Yang Wang, Baojie Li, Guoyin Feng, Lin He, Yongyong Shi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/668effc546a545e6bc155e0f90326e66
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spelling	oai:doaj.org-article:668effc546a545e6bc155e0f90326e662021-11-18T07:02:47ZCommon SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.1932-620310.1371/journal.pone.0013662https://doaj.org/article/668effc546a545e6bc155e0f90326e662010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21048971/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD.<h4>Methods</h4>In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin.<h4>Results</h4>Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007).<h4>Conclusion</h4>Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population.Ti WangZhen ZengTao LiJie LiuJunyan LiYou LiQian ZhaoZhiyun WeiYang WangBaojie LiGuoyin FengLin HeYongyong ShiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13662 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ti Wang Zhen Zeng Tao Li Jie Liu Junyan Li You Li Qian Zhao Zhiyun Wei Yang Wang Baojie Li Guoyin Feng Lin He Yongyong Shi Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.
description	<h4>Background</h4>Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD.<h4>Methods</h4>In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin.<h4>Results</h4>Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007).<h4>Conclusion</h4>Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population.
format	article
author	Ti Wang Zhen Zeng Tao Li Jie Liu Junyan Li You Li Qian Zhao Zhiyun Wei Yang Wang Baojie Li Guoyin Feng Lin He Yongyong Shi
author_facet	Ti Wang Zhen Zeng Tao Li Jie Liu Junyan Li You Li Qian Zhao Zhiyun Wei Yang Wang Baojie Li Guoyin Feng Lin He Yongyong Shi
author_sort	Ti Wang
title	Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.
title_short	Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.
title_full	Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.
title_fullStr	Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.
title_full_unstemmed	Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.
title_sort	common snps in myelin transcription factor 1-like (myt1l): association with major depressive disorder in the chinese han population.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/668effc546a545e6bc155e0f90326e66
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Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population.

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