Intravenous Immunoglobulin and its Complications

Intravenous immunoglobulin (IVIG) is a safe biological product used in many cases, such as primary and secondary immune deficiency, infectious diseases, critically ill patients and autoimmune disorders. IVIG has many advantages compared with intramuscular immunoglobulin and is obtained from pooled p...

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Autor principal:	I Mohammadzadeh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	intravenous immunoglobulin children complications Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/668f3ba8a1eb4699a17347f2d603f330
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spelling	oai:doaj.org-article:668f3ba8a1eb4699a17347f2d603f3302021-11-10T08:56:35ZIntravenous Immunoglobulin and its Complications1561-41072251-7170https://doaj.org/article/668f3ba8a1eb4699a17347f2d603f3302011-05-01T00:00:00Zhttp://jbums.org/article-1-3807-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Intravenous immunoglobulin (IVIG) is a safe biological product used in many cases, such as primary and secondary immune deficiency, infectious diseases, critically ill patients and autoimmune disorders. IVIG has many advantages compared with intramuscular immunoglobulin and is obtained from pooled plasma of 10.000-60.000 donors. Today, IVIG use in clinical settings has increased. Despite its use in many diseases, FDA only has approved its use in patients suffering from ITP, primary immunodeficiency, pediatric HIV, Kawasaki disease, bone marrow transplantation and B-cells chronic lymphocytic leukemia. But, it has been used for other cases like Guillain–Barré syndrome, premature infants, critically ill patients admitted to ICU, severe asthma and uncontrolled seizures which FDA had not approved yet.This biological product affects immune deficiency and autoimmune diseases in different ways. Despite the relative safety of this product, the patient may experience mild but acute complications.In most cases acute reaction is due to high speed infusion rate which is mild but systemic side effects in the form of allergic and non-allergic anaphylaxis are seen, especially in patients with CVID and IgA selective deficiency. The patient should be under medical supervision during infusion and to deal with anaphylaxis shock, facilities should be available. Today, the subcutaneous type of immunoglobulin is used at home under supervision of a nurse and the patient satisfaction is high, because of its lower cost and also it does not need hospital admission.I MohammadzadehBabol University of Medical Sciencesarticleintravenous immunoglobulinchildrencomplicationsMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 3, Pp 80-89 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	intravenous immunoglobulin children complications Medicine R Medicine (General) R5-920
spellingShingle	intravenous immunoglobulin children complications Medicine R Medicine (General) R5-920 I Mohammadzadeh Intravenous Immunoglobulin and its Complications
description	Intravenous immunoglobulin (IVIG) is a safe biological product used in many cases, such as primary and secondary immune deficiency, infectious diseases, critically ill patients and autoimmune disorders. IVIG has many advantages compared with intramuscular immunoglobulin and is obtained from pooled plasma of 10.000-60.000 donors. Today, IVIG use in clinical settings has increased. Despite its use in many diseases, FDA only has approved its use in patients suffering from ITP, primary immunodeficiency, pediatric HIV, Kawasaki disease, bone marrow transplantation and B-cells chronic lymphocytic leukemia. But, it has been used for other cases like Guillain–Barré syndrome, premature infants, critically ill patients admitted to ICU, severe asthma and uncontrolled seizures which FDA had not approved yet.This biological product affects immune deficiency and autoimmune diseases in different ways. Despite the relative safety of this product, the patient may experience mild but acute complications.In most cases acute reaction is due to high speed infusion rate which is mild but systemic side effects in the form of allergic and non-allergic anaphylaxis are seen, especially in patients with CVID and IgA selective deficiency. The patient should be under medical supervision during infusion and to deal with anaphylaxis shock, facilities should be available. Today, the subcutaneous type of immunoglobulin is used at home under supervision of a nurse and the patient satisfaction is high, because of its lower cost and also it does not need hospital admission.
format	article
author	I Mohammadzadeh
author_facet	I Mohammadzadeh
author_sort	I Mohammadzadeh
title	Intravenous Immunoglobulin and its Complications
title_short	Intravenous Immunoglobulin and its Complications
title_full	Intravenous Immunoglobulin and its Complications
title_fullStr	Intravenous Immunoglobulin and its Complications
title_full_unstemmed	Intravenous Immunoglobulin and its Complications
title_sort	intravenous immunoglobulin and its complications
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/668f3ba8a1eb4699a17347f2d603f330
work_keys_str_mv	AT imohammadzadeh intravenousimmunoglobulinanditscomplications
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Intravenous Immunoglobulin and its Complications

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