Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage
Xiuqun Gong,1,* Zeyu Lu,2,* Xiwu Feng,3,* Chuanqing Yu,1 Min Xue,1 Liang Yu,1 Tao Wang,1 Xiaosi Cheng,1 Jun Lu,4,5 Mei Zhang1 1Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6691712d077d4dc6b2939394eda9719c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6691712d077d4dc6b2939394eda9719c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6691712d077d4dc6b2939394eda9719c2021-12-02T11:00:38ZElevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage1178-2021https://doaj.org/article/6691712d077d4dc6b2939394eda9719c2020-09-01T00:00:00Zhttps://www.dovepress.com/elevated-neutrophil-to-lymphocyte-ratio-predicts-depression-after-intr-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiuqun Gong,1,* Zeyu Lu,2,* Xiwu Feng,3,* Chuanqing Yu,1 Min Xue,1 Liang Yu,1 Tao Wang,1 Xiaosi Cheng,1 Jun Lu,4,5 Mei Zhang1 1Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China; 2School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, People’s Republic of China; 3Department of Cardiothoracic Surgery, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China; 4Department of Medical Laboratory, School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, People’s Republic of China; 5Department of Clinical Laboratory, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun LuDepartment of Medical Laboratory, School of Medicine, Anhui University of Science and Technology, 168 Taifeng Road, Huainan 232001, Anhui Province, People’s Republic of ChinaTel +86- 13855453149Email cfdxlujun@126.comMei ZhangDepartment of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, 203 Huaibin Road, Huainan 232007, Anhui Province, People’s Republic of ChinaTel + 86- 13955466855Email hnzhangmei2008@163.comPurpose: Inflammation plays a critical role in the development of depression after intracerebral hemorrhage (ICH), while neutrophil-to-lymphocyte ratio (NLR) has been identified as a novel comprehensive inflammatory indicator in recent years. The aim of this study was to examine the association between NLR and depression after ICH.Patients and Methods: From January 2016 to December 2018, ICH patients were prospectively enrolled. NLR was measured at admission. Depression at 3 months after ICH was diagnosed according to the Hamilton Depression Scale (HAMD).Results: Of the 372 enrolled patients, 107 (28.8%) were diagnosed with depression at 3 months after ICH. Patients with depression had a higher NLR (6.15 vs 3.55, P < 0.001). Logistic regression analysis detected that after adjusting for major confounders, NLR remained independently associated with depression after ICH (OR = 2.25, 95% CI: 1.45– 3.49, P < 0.001). Moreover, NLR acted as the optimal variable for prediction, with the optimal predictive threshold of 4.53 in ROC analysis.Conclusion: Elevated NLR is associated with depression at 3 months after ICH, suggesting that NLR may be a significant biomarker to predict depression after ICH.Keywords: inflammation, neutrophil-to-lymphocyte ratio, depression, intracerebral hemorrhageGong XLu ZFeng XYu CXue MYu LWang TCheng XLu JZhang MDove Medical Pressarticleinflammationneutrophil to lymphocyte ratiodepressionintracerebral hemorrhageNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2153-2159 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
inflammation neutrophil to lymphocyte ratio depression intracerebral hemorrhage Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
inflammation neutrophil to lymphocyte ratio depression intracerebral hemorrhage Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gong X Lu Z Feng X Yu C Xue M Yu L Wang T Cheng X Lu J Zhang M Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage |
| description |
Xiuqun Gong,1,* Zeyu Lu,2,* Xiwu Feng,3,* Chuanqing Yu,1 Min Xue,1 Liang Yu,1 Tao Wang,1 Xiaosi Cheng,1 Jun Lu,4,5 Mei Zhang1 1Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China; 2School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, People’s Republic of China; 3Department of Cardiothoracic Surgery, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China; 4Department of Medical Laboratory, School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui, People’s Republic of China; 5Department of Clinical Laboratory, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan 232001, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun LuDepartment of Medical Laboratory, School of Medicine, Anhui University of Science and Technology, 168 Taifeng Road, Huainan 232001, Anhui Province, People’s Republic of ChinaTel +86- 13855453149Email cfdxlujun@126.comMei ZhangDepartment of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, 203 Huaibin Road, Huainan 232007, Anhui Province, People’s Republic of ChinaTel + 86- 13955466855Email hnzhangmei2008@163.comPurpose: Inflammation plays a critical role in the development of depression after intracerebral hemorrhage (ICH), while neutrophil-to-lymphocyte ratio (NLR) has been identified as a novel comprehensive inflammatory indicator in recent years. The aim of this study was to examine the association between NLR and depression after ICH.Patients and Methods: From January 2016 to December 2018, ICH patients were prospectively enrolled. NLR was measured at admission. Depression at 3 months after ICH was diagnosed according to the Hamilton Depression Scale (HAMD).Results: Of the 372 enrolled patients, 107 (28.8%) were diagnosed with depression at 3 months after ICH. Patients with depression had a higher NLR (6.15 vs 3.55, P < 0.001). Logistic regression analysis detected that after adjusting for major confounders, NLR remained independently associated with depression after ICH (OR = 2.25, 95% CI: 1.45– 3.49, P < 0.001). Moreover, NLR acted as the optimal variable for prediction, with the optimal predictive threshold of 4.53 in ROC analysis.Conclusion: Elevated NLR is associated with depression at 3 months after ICH, suggesting that NLR may be a significant biomarker to predict depression after ICH.Keywords: inflammation, neutrophil-to-lymphocyte ratio, depression, intracerebral hemorrhage |
| format |
article |
| author |
Gong X Lu Z Feng X Yu C Xue M Yu L Wang T Cheng X Lu J Zhang M |
| author_facet |
Gong X Lu Z Feng X Yu C Xue M Yu L Wang T Cheng X Lu J Zhang M |
| author_sort |
Gong X |
| title |
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage |
| title_short |
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage |
| title_full |
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage |
| title_fullStr |
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage |
| title_full_unstemmed |
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage |
| title_sort |
elevated neutrophil-to-lymphocyte ratio predicts depression after intracerebral hemorrhage |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/6691712d077d4dc6b2939394eda9719c |
| work_keys_str_mv |
AT gongx elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT luz elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT fengx elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT yuc elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT xuem elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT yul elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT wangt elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT chengx elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT luj elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage AT zhangm elevatedneutrophiltolymphocyteratiopredictsdepressionafterintracerebralhemorrhage |
| _version_ |
1718396357393252352 |