Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice

Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmic...

Full description

Saved in:

Bibliographic Details
Main Authors:	Gang Han, Ben Gu, Limin Cao, Xianjun Gao, Qingsong Wang, Yiqi Seow, Ning Zhang, Matthew J. A. Wood, HaiFang Yin
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/6693a2a52ec647acbff8c2322364c6d0
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:6693a2a52ec647acbff8c2322364c6d0
record_format	dspace
spelling	oai:doaj.org-article:6693a2a52ec647acbff8c2322364c6d02021-12-02T17:32:39ZHexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice10.1038/ncomms109812041-1723https://doaj.org/article/6693a2a52ec647acbff8c2322364c6d02016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10981https://doaj.org/toc/2041-1723Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmice.Gang HanBen GuLimin CaoXianjun GaoQingsong WangYiqi SeowNing ZhangMatthew J. A. WoodHaiFang YinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Han Ben Gu Limin Cao Xianjun Gao Qingsong Wang Yiqi Seow Ning Zhang Matthew J. A. Wood HaiFang Yin Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
description	Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmice.
format	article
author	Gang Han Ben Gu Limin Cao Xianjun Gao Qingsong Wang Yiqi Seow Ning Zhang Matthew J. A. Wood HaiFang Yin
author_facet	Gang Han Ben Gu Limin Cao Xianjun Gao Qingsong Wang Yiqi Seow Ning Zhang Matthew J. A. Wood HaiFang Yin
author_sort	Gang Han
title	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_short	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_full	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_fullStr	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_full_unstemmed	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_sort	hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6693a2a52ec647acbff8c2322364c6d0
work_keys_str_mv	AT ganghan hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT bengu hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT limincao hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT xianjungao hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT qingsongwang hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT yiqiseow hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT ningzhang hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT matthewjawood hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice AT haifangyin hexoseenhancesoligonucleotidedeliveryandexonskippingindystrophindeficientmdxmice
_version_	1718380252305031168

Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice

Similar Items