Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice

Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmic...

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Autores principales:	Gang Han, Ben Gu, Limin Cao, Xianjun Gao, Qingsong Wang, Yiqi Seow, Ning Zhang, Matthew J. A. Wood, HaiFang Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6693a2a52ec647acbff8c2322364c6d0
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spelling	oai:doaj.org-article:6693a2a52ec647acbff8c2322364c6d02021-12-02T17:32:39ZHexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice10.1038/ncomms109812041-1723https://doaj.org/article/6693a2a52ec647acbff8c2322364c6d02016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10981https://doaj.org/toc/2041-1723Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmice.Gang HanBen GuLimin CaoXianjun GaoQingsong WangYiqi SeowNing ZhangMatthew J. A. WoodHaiFang YinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Han Ben Gu Limin Cao Xianjun Gao Qingsong Wang Yiqi Seow Ning Zhang Matthew J. A. Wood HaiFang Yin Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
description	Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmice.
format	article
author	Gang Han Ben Gu Limin Cao Xianjun Gao Qingsong Wang Yiqi Seow Ning Zhang Matthew J. A. Wood HaiFang Yin
author_facet	Gang Han Ben Gu Limin Cao Xianjun Gao Qingsong Wang Yiqi Seow Ning Zhang Matthew J. A. Wood HaiFang Yin
author_sort	Gang Han
title	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_short	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_full	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_fullStr	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_full_unstemmed	Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
title_sort	hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6693a2a52ec647acbff8c2322364c6d0
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Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice

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