Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

Background. Hypertensive glaucoma (HTG) causes damage to the retinal ganglion cells and eventually to the entire visual pathway due to high intraocular pressure (IOP). However, increased IOP will also affect the vessel density (VD) of the posterior pole of the eye and the related retinal ganglion ne...

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Autores principales:	Marketa Zakova, Jan Lestak, Martin Fus, Klara Maresova
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	retinal nerve fibre layer optical coherence tomography angiography vessel density visual field hypertensive glaucoma normotensive glaucoma Medicine R
Acceso en línea:	https://doaj.org/article/66960238c4c04d41aea54f930303d7b0
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spelling	oai:doaj.org-article:66960238c4c04d41aea54f930303d7b02021-11-29T09:17:21ZOptical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma1213-81181804-7521https://doaj.org/article/66960238c4c04d41aea54f930303d7b02021-11-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202104-0014_optical-coherence-tomography-angiography-and-the-visual-field-in-hypertensive-and-normotensive-glaucoma.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Background. Hypertensive glaucoma (HTG) causes damage to the retinal ganglion cells and eventually to the entire visual pathway due to high intraocular pressure (IOP). However, increased IOP will also affect the vessel density (VD) of the posterior pole of the eye and the related retinal ganglion nerve fibres (RNFL). In normotensive glaucoma (NTG), the retinal ganglion cells are relatively intact. The pathology is at the level of ganglion fibres. The unanswered question is what has altered ganglion cell fibres at the level of the retina and optic nerve head in NTG? Aim. The aim of this study was to determine whether there is a correlation between the retinal nerve fibre layer (RNFL) and vessel density (VD) at the same altitudinal half of the retina and the sum of sensitivities of the contralateral half of the visual field of the same eye in hypertensive and normotensive glaucoma (NTG). Methods. Our group included 20 patients with HTG and 20 patients with NTG. The Pearson's correlation coefficient r was used for evaluation of the relationship of the peripapillary RNFL and VD, visual field (using the fast threshold glaucoma program) as the sum of sensitivities in apostilbs (asb) to the extent of 0-22 degrees. The results of sensitivity were compared with the RNFL and VD of the contralateral altitudinal half of the retina in the same eye. Results. In the HTG group there was a moderate relationship between RNFL and VD (both hemifields), but no relationship between RNFL and VF. VD SH and VF IH showed weak correlation and VD IH and VF SH showed no correlation. In patients with NTG, we found a strong correlation between RNFL and VD (both hemifields), between VD SH and VF IH a moderate correlation, between VD IH and VF SH also a moderate correlation and a weak correlation between RNFL and VF. Conclusion. By comparing the RNFL and VD at the same altitudinal halves of the retina, we found a moderate correlation in HTG and a strong correlation in NTG. We found no or a weak correlation between VD and VF in HTG. In NTG the relationship between VD and VF showed a strong correlation. These findings reveal the differences in the diagnostic groups.Marketa ZakovaJan LestakMartin FusKlara MaresovaPalacký University Olomouc, Faculty of Medicine and Dentistryarticleretinal nerve fibre layeroptical coherence tomography angiographyvessel densityvisual fieldhypertensive glaucomanormotensive glaucomaMedicineRENBiomedical Papers, Vol 165, Iss 4, Pp 441-444 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinal nerve fibre layer optical coherence tomography angiography vessel density visual field hypertensive glaucoma normotensive glaucoma Medicine R
spellingShingle	retinal nerve fibre layer optical coherence tomography angiography vessel density visual field hypertensive glaucoma normotensive glaucoma Medicine R Marketa Zakova Jan Lestak Martin Fus Klara Maresova Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma
description	Background. Hypertensive glaucoma (HTG) causes damage to the retinal ganglion cells and eventually to the entire visual pathway due to high intraocular pressure (IOP). However, increased IOP will also affect the vessel density (VD) of the posterior pole of the eye and the related retinal ganglion nerve fibres (RNFL). In normotensive glaucoma (NTG), the retinal ganglion cells are relatively intact. The pathology is at the level of ganglion fibres. The unanswered question is what has altered ganglion cell fibres at the level of the retina and optic nerve head in NTG? Aim. The aim of this study was to determine whether there is a correlation between the retinal nerve fibre layer (RNFL) and vessel density (VD) at the same altitudinal half of the retina and the sum of sensitivities of the contralateral half of the visual field of the same eye in hypertensive and normotensive glaucoma (NTG). Methods. Our group included 20 patients with HTG and 20 patients with NTG. The Pearson's correlation coefficient r was used for evaluation of the relationship of the peripapillary RNFL and VD, visual field (using the fast threshold glaucoma program) as the sum of sensitivities in apostilbs (asb) to the extent of 0-22 degrees. The results of sensitivity were compared with the RNFL and VD of the contralateral altitudinal half of the retina in the same eye. Results. In the HTG group there was a moderate relationship between RNFL and VD (both hemifields), but no relationship between RNFL and VF. VD SH and VF IH showed weak correlation and VD IH and VF SH showed no correlation. In patients with NTG, we found a strong correlation between RNFL and VD (both hemifields), between VD SH and VF IH a moderate correlation, between VD IH and VF SH also a moderate correlation and a weak correlation between RNFL and VF. Conclusion. By comparing the RNFL and VD at the same altitudinal halves of the retina, we found a moderate correlation in HTG and a strong correlation in NTG. We found no or a weak correlation between VD and VF in HTG. In NTG the relationship between VD and VF showed a strong correlation. These findings reveal the differences in the diagnostic groups.
format	article
author	Marketa Zakova Jan Lestak Martin Fus Klara Maresova
author_facet	Marketa Zakova Jan Lestak Martin Fus Klara Maresova
author_sort	Marketa Zakova
title	Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma
title_short	Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma
title_full	Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma
title_fullStr	Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma
title_full_unstemmed	Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma
title_sort	optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/66960238c4c04d41aea54f930303d7b0
work_keys_str_mv	AT marketazakova opticalcoherencetomographyangiographyandthevisualfieldinhypertensiveandnormotensiveglaucoma AT janlestak opticalcoherencetomographyangiographyandthevisualfieldinhypertensiveandnormotensiveglaucoma AT martinfus opticalcoherencetomographyangiographyandthevisualfieldinhypertensiveandnormotensiveglaucoma AT klaramaresova opticalcoherencetomographyangiographyandthevisualfieldinhypertensiveandnormotensiveglaucoma
_version_	1718407403901288448

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

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