Phase separation-deficient TDP43 remains functional in splicing

TDP43 regulates RNA processing and undergoes liquid-liquid phase separation. Here, the authors combine bioinformatic analysis and quantitative measurements of phase properties in living cells to uncover the rules that link the amino acid sequence of TDP43 with its phase properties and find that unex...

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Autores principales:	Hermann Broder Schmidt, Ariana Barreau, Rajat Rohatgi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/669a599713dd4365a9515ad591a4ae22
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id	oai:doaj.org-article:669a599713dd4365a9515ad591a4ae22
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spelling	oai:doaj.org-article:669a599713dd4365a9515ad591a4ae222021-12-02T15:36:20ZPhase separation-deficient TDP43 remains functional in splicing10.1038/s41467-019-12740-22041-1723https://doaj.org/article/669a599713dd4365a9515ad591a4ae222019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12740-2https://doaj.org/toc/2041-1723TDP43 regulates RNA processing and undergoes liquid-liquid phase separation. Here, the authors combine bioinformatic analysis and quantitative measurements of phase properties in living cells to uncover the rules that link the amino acid sequence of TDP43 with its phase properties and find that unexpectedly, mutants of TDP43 that are deficient in phase separation can still function to mediate splicing.Hermann Broder SchmidtAriana BarreauRajat RohatgiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hermann Broder Schmidt Ariana Barreau Rajat Rohatgi Phase separation-deficient TDP43 remains functional in splicing
description	TDP43 regulates RNA processing and undergoes liquid-liquid phase separation. Here, the authors combine bioinformatic analysis and quantitative measurements of phase properties in living cells to uncover the rules that link the amino acid sequence of TDP43 with its phase properties and find that unexpectedly, mutants of TDP43 that are deficient in phase separation can still function to mediate splicing.
format	article
author	Hermann Broder Schmidt Ariana Barreau Rajat Rohatgi
author_facet	Hermann Broder Schmidt Ariana Barreau Rajat Rohatgi
author_sort	Hermann Broder Schmidt
title	Phase separation-deficient TDP43 remains functional in splicing
title_short	Phase separation-deficient TDP43 remains functional in splicing
title_full	Phase separation-deficient TDP43 remains functional in splicing
title_fullStr	Phase separation-deficient TDP43 remains functional in splicing
title_full_unstemmed	Phase separation-deficient TDP43 remains functional in splicing
title_sort	phase separation-deficient tdp43 remains functional in splicing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/669a599713dd4365a9515ad591a4ae22
work_keys_str_mv	AT hermannbroderschmidt phaseseparationdeficienttdp43remainsfunctionalinsplicing AT arianabarreau phaseseparationdeficienttdp43remainsfunctionalinsplicing AT rajatrohatgi phaseseparationdeficienttdp43remainsfunctionalinsplicing
_version_	1718386292551581696

Phase separation-deficient TDP43 remains functional in splicing

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