Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type, and treatment have not been comprehensively studied together. We used an induced pluripotent stem cell system to study multiple cell types derived fr...

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Autores principales:	Anthony S Findley, Alan Monziani, Allison L Richards, Katherine Rhodes, Michelle C Ward, Cynthia A Kalita, Adnan Alazizi, Ali Pazokitoroudi, Sriram Sankararaman, Xiaoquan Wen, David E Lanfear, Roger Pique-Regi, Yoav Gilad, Francesca Luca
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	allele specific expression GxE gene regulation cardiovascular disease IPSC regulatory variants Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/669e7973fff1476c8b8f49f8daf487c0
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Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

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