Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type, and treatment have not been comprehensively studied together. We used an induced pluripotent stem cell system to study multiple cell types derived fr...

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Bibliographic Details
Main Authors: Anthony S Findley, Alan Monziani, Allison L Richards, Katherine Rhodes, Michelle C Ward, Cynthia A Kalita, Adnan Alazizi, Ali Pazokitoroudi, Sriram Sankararaman, Xiaoquan Wen, David E Lanfear, Roger Pique-Regi, Yoav Gilad, Francesca Luca
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
allele specific expression
GxE
gene regulation
cardiovascular disease
IPSC
regulatory variants
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/669e7973fff1476c8b8f49f8daf487c0
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https://doaj.org/article/669e7973fff1476c8b8f49f8daf487c0

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