α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parki...

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Autores principales:	Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66a1b1816bc747869ab5c60b308732ab
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spelling	oai:doaj.org-article:66a1b1816bc747869ab5c60b308732ab2021-12-02T16:49:49Zα-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease10.1038/s41467-018-04422-22041-1723https://doaj.org/article/66a1b1816bc747869ab5c60b308732ab2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04422-2https://doaj.org/toc/2041-1723How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parkinson’s disease.Marthe H. R. LudtmannPlamena R. AngelovaMathew H. HorrocksMinee L. ChoiMargarida RodriguesArtyom Y. BaevAlexey V. BerezhnovZhi YaoDaniel LittleBlerida BanushiAfnan Saleh Al-MenhaliRohan T. RanasingheDaniel R. WhitenRatsuda YapomKaramjit Singh DoltMichael J. DevinePaul GissenTilo KunathMorana JaganjacEvgeny V. PavlovDavid KlenermanAndrey Y. AbramovSonia GandhiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marthe H. R. Ludtmann Plamena R. Angelova Mathew H. Horrocks Minee L. Choi Margarida Rodrigues Artyom Y. Baev Alexey V. Berezhnov Zhi Yao Daniel Little Blerida Banushi Afnan Saleh Al-Menhali Rohan T. Ranasinghe Daniel R. Whiten Ratsuda Yapom Karamjit Singh Dolt Michael J. Devine Paul Gissen Tilo Kunath Morana Jaganjac Evgeny V. Pavlov David Klenerman Andrey Y. Abramov Sonia Gandhi α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
description	How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parkinson’s disease.
format	article
author	Marthe H. R. Ludtmann Plamena R. Angelova Mathew H. Horrocks Minee L. Choi Margarida Rodrigues Artyom Y. Baev Alexey V. Berezhnov Zhi Yao Daniel Little Blerida Banushi Afnan Saleh Al-Menhali Rohan T. Ranasinghe Daniel R. Whiten Ratsuda Yapom Karamjit Singh Dolt Michael J. Devine Paul Gissen Tilo Kunath Morana Jaganjac Evgeny V. Pavlov David Klenerman Andrey Y. Abramov Sonia Gandhi
author_facet	Marthe H. R. Ludtmann Plamena R. Angelova Mathew H. Horrocks Minee L. Choi Margarida Rodrigues Artyom Y. Baev Alexey V. Berezhnov Zhi Yao Daniel Little Blerida Banushi Afnan Saleh Al-Menhali Rohan T. Ranasinghe Daniel R. Whiten Ratsuda Yapom Karamjit Singh Dolt Michael J. Devine Paul Gissen Tilo Kunath Morana Jaganjac Evgeny V. Pavlov David Klenerman Andrey Y. Abramov Sonia Gandhi
author_sort	Marthe H. R. Ludtmann
title	α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
title_short	α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
title_full	α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
title_fullStr	α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
title_full_unstemmed	α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
title_sort	α-synuclein oligomers interact with atp synthase and open the permeability transition pore in parkinson’s disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/66a1b1816bc747869ab5c60b308732ab
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

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