Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.

Regulation of polarised cell growth is essential for many cellular processes including spatial coordination of cell morphology changes during the division cycle. We present a mathematical model of the core mechanism responsible for the regulation of polarised growth dynamics during the fission yeast...

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Autores principales:	Luca Cerone, Béla Novák, Zoltán Neufeld
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66a203a4d2944f998e9018e42df2b07d
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spelling	oai:doaj.org-article:66a203a4d2944f998e9018e42df2b07d2021-11-18T08:07:31ZMathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.1932-620310.1371/journal.pone.0049675https://doaj.org/article/66a203a4d2944f998e9018e42df2b07d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209589/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Regulation of polarised cell growth is essential for many cellular processes including spatial coordination of cell morphology changes during the division cycle. We present a mathematical model of the core mechanism responsible for the regulation of polarised growth dynamics during the fission yeast cell cycle. The model is based on the competition of growth zones localised at the cell tips for a common substrate distributed uniformly in the cytosol. We analyse the bifurcations in this model as the cell length increases, and show that the growth activation dynamics provides an explanation for the new-end take-off (NETO) as a saddle-node bifurcation at which the cell sharply switches from monopolar to bipolar growth. We study the parameter sensitivity of the bifurcation diagram and relate qualitative changes of the growth pattern, e.g. delayed or absent NETO, to previously observed mutant phenotypes. We investigate the effects of imperfect asymmetric cell division, and show that this leads to distinct growth patterns that provide experimentally testable predictions for validating the presented competitive growth zone activation model. Finally we discuss extension of the model for describing mutant cells with more than two growth zones.Luca CeroneBéla NovákZoltán NeufeldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49675 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luca Cerone Béla Novák Zoltán Neufeld Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.
description	Regulation of polarised cell growth is essential for many cellular processes including spatial coordination of cell morphology changes during the division cycle. We present a mathematical model of the core mechanism responsible for the regulation of polarised growth dynamics during the fission yeast cell cycle. The model is based on the competition of growth zones localised at the cell tips for a common substrate distributed uniformly in the cytosol. We analyse the bifurcations in this model as the cell length increases, and show that the growth activation dynamics provides an explanation for the new-end take-off (NETO) as a saddle-node bifurcation at which the cell sharply switches from monopolar to bipolar growth. We study the parameter sensitivity of the bifurcation diagram and relate qualitative changes of the growth pattern, e.g. delayed or absent NETO, to previously observed mutant phenotypes. We investigate the effects of imperfect asymmetric cell division, and show that this leads to distinct growth patterns that provide experimentally testable predictions for validating the presented competitive growth zone activation model. Finally we discuss extension of the model for describing mutant cells with more than two growth zones.
format	article
author	Luca Cerone Béla Novák Zoltán Neufeld
author_facet	Luca Cerone Béla Novák Zoltán Neufeld
author_sort	Luca Cerone
title	Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.
title_short	Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.
title_full	Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.
title_fullStr	Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.
title_full_unstemmed	Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.
title_sort	mathematical model for growth regulation of fission yeast schizosaccharomyces pombe.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/66a203a4d2944f998e9018e42df2b07d
work_keys_str_mv	AT lucacerone mathematicalmodelforgrowthregulationoffissionyeastschizosaccharomycespombe AT belanovak mathematicalmodelforgrowthregulationoffissionyeastschizosaccharomycespombe AT zoltanneufeld mathematicalmodelforgrowthregulationoffissionyeastschizosaccharomycespombe
_version_	1718422171755216896

Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.

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