The Potential Role of miRNAs in Cognitive Frailty

Frailty is an aging related condition, which has been defined as a state of enhanced vulnerability to stressors, leading to a limited capacity to meet homeostatic demands. Cognitive impairment is also frequent in older people, often accompanying frailty. Age is the main independent risk factor for b...

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Autores principales:	Giulia Carini, Laura Musazzi, Francesco Bolzetta, Alberto Cester, Chiara Fiorentini, Alessandro Ieraci, Stefania Maggi, Maurizio Popoli, Nicola Veronese, Alessandro Barbon
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	frailty cognitive frailty biomarkers miRNA–microRNA cognitive impairment MCI (mild cognitive impairment) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/66a983faa4dd4a1c94afa1f94ecc275c
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id	oai:doaj.org-article:66a983faa4dd4a1c94afa1f94ecc275c
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spelling	oai:doaj.org-article:66a983faa4dd4a1c94afa1f94ecc275c2021-11-12T05:20:58ZThe Potential Role of miRNAs in Cognitive Frailty1663-436510.3389/fnagi.2021.763110https://doaj.org/article/66a983faa4dd4a1c94afa1f94ecc275c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.763110/fullhttps://doaj.org/toc/1663-4365Frailty is an aging related condition, which has been defined as a state of enhanced vulnerability to stressors, leading to a limited capacity to meet homeostatic demands. Cognitive impairment is also frequent in older people, often accompanying frailty. Age is the main independent risk factor for both frailty and cognitive impairment, and compelling evidence suggests that similar age-associated mechanisms could underlie both clinical conditions. Accordingly, it has been suggested that frailty and cognitive impairment share common pathways, and some authors proposed “cognitive frailty” as a single complex phenotype. Nevertheless, so far, no clear common underlying pathways have been discovered for both conditions. microRNAs (miRNAs) have emerged as key fine-tuning regulators in most physiological processes, as well as pathological conditions. Importantly, miRNAs have been proposed as both peripheral biomarkers and potential molecular factors involved in physiological and pathological aging. In this review, we discuss the evidence linking changes of selected miRNAs expression with frailty and cognitive impairment. Overall, miR-92a-5p and miR-532-5p, as well as other miRNAs implicated in pathological aging, should be investigated as potential biomarkers (and putative molecular effectors) of cognitive frailty.Giulia CariniLaura MusazziFrancesco BolzettaAlberto CesterChiara FiorentiniAlessandro IeraciStefania MaggiMaurizio PopoliNicola VeroneseNicola VeroneseAlessandro BarbonFrontiers Media S.A.articlefrailtycognitive frailtybiomarkersmiRNA–microRNAcognitive impairmentMCI (mild cognitive impairment)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty cognitive frailty biomarkers miRNA–microRNA cognitive impairment MCI (mild cognitive impairment) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	frailty cognitive frailty biomarkers miRNA–microRNA cognitive impairment MCI (mild cognitive impairment) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Giulia Carini Laura Musazzi Francesco Bolzetta Alberto Cester Chiara Fiorentini Alessandro Ieraci Stefania Maggi Maurizio Popoli Nicola Veronese Nicola Veronese Alessandro Barbon The Potential Role of miRNAs in Cognitive Frailty
description	Frailty is an aging related condition, which has been defined as a state of enhanced vulnerability to stressors, leading to a limited capacity to meet homeostatic demands. Cognitive impairment is also frequent in older people, often accompanying frailty. Age is the main independent risk factor for both frailty and cognitive impairment, and compelling evidence suggests that similar age-associated mechanisms could underlie both clinical conditions. Accordingly, it has been suggested that frailty and cognitive impairment share common pathways, and some authors proposed “cognitive frailty” as a single complex phenotype. Nevertheless, so far, no clear common underlying pathways have been discovered for both conditions. microRNAs (miRNAs) have emerged as key fine-tuning regulators in most physiological processes, as well as pathological conditions. Importantly, miRNAs have been proposed as both peripheral biomarkers and potential molecular factors involved in physiological and pathological aging. In this review, we discuss the evidence linking changes of selected miRNAs expression with frailty and cognitive impairment. Overall, miR-92a-5p and miR-532-5p, as well as other miRNAs implicated in pathological aging, should be investigated as potential biomarkers (and putative molecular effectors) of cognitive frailty.
format	article
author	Giulia Carini Laura Musazzi Francesco Bolzetta Alberto Cester Chiara Fiorentini Alessandro Ieraci Stefania Maggi Maurizio Popoli Nicola Veronese Nicola Veronese Alessandro Barbon
author_facet	Giulia Carini Laura Musazzi Francesco Bolzetta Alberto Cester Chiara Fiorentini Alessandro Ieraci Stefania Maggi Maurizio Popoli Nicola Veronese Nicola Veronese Alessandro Barbon
author_sort	Giulia Carini
title	The Potential Role of miRNAs in Cognitive Frailty
title_short	The Potential Role of miRNAs in Cognitive Frailty
title_full	The Potential Role of miRNAs in Cognitive Frailty
title_fullStr	The Potential Role of miRNAs in Cognitive Frailty
title_full_unstemmed	The Potential Role of miRNAs in Cognitive Frailty
title_sort	potential role of mirnas in cognitive frailty
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/66a983faa4dd4a1c94afa1f94ecc275c
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The Potential Role of miRNAs in Cognitive Frailty

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