Interleukin role in the regulation of endothelial cell pathological activation

Interleukins (ILs) are the group of cytokines firstly identified as expressed by leukocytes and playing different immunomodulatory functions. With increasing evidence of a constant crosstalk between leukocytes and endothelial cells in the regulation of immune cell differentiation and activation, a r...

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Autores principales:	Maria Luigia Carbone, Cristina Maria Failla
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	interleukins endothelial cells inflammation angiogenesis Diseases of the circulatory (Cardiovascular) system RC666-701 Physiology QP1-981
Acceso en línea:	https://doi.org/10.1530/VB-21-0010 https://doaj.org/article/66aa131d9879485e9699e91444475108
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spelling	oai:doaj.org-article:66aa131d9879485e9699e914444751082021-11-16T09:14:12ZInterleukin role in the regulation of endothelial cell pathological activationhttps://doi.org/10.1530/VB-21-00102516-5658https://doaj.org/article/66aa131d9879485e9699e914444751082021-11-01T00:00:00Zhttps://vb.bioscientifica.com/view/journals/vb/3/1/VB-21-0010.xmlhttps://doaj.org/toc/2516-5658Interleukins (ILs) are the group of cytokines firstly identified as expressed by leukocytes and playing different immunomodulatory functions. With increasing evidence of a constant crosstalk between leukocytes and endothelial cells in the regulation of immune cell differentiation and activation, a role of ILs also in endothelial cell stimulation and vascular inflammation has been shown. ILs act on endothelial cells both in an autocrine and a paracrine manner. In fact, a cross regulation is present among ILs expressed by different cell types, leading to amplification or blocking of the initial inflammatory signal with the secretion of additional ILs or involvement of other adjacent cells and tissues. Based on selective structural features, ILs can be divided into four major groups, a fifth group comprises ILs that do not fit into any of the other four. Most of the ILs playing a role in endothelial cell activation belong to the IL1-like cytokine group, but the number of ILs involved in vascular inflammation is constantly growing, and a special contribution of IL6, IL8, and IL17 has been underlined. This review aims at presenting current knowledge and at underling missing information about the role of IL in activating endothelial cells in selected pathological settings such as tumours, psoriasis, systemic sclerosis, and viral infection.Maria Luigia CarboneCristina Maria FaillaBioscientificaarticleinterleukinsendothelial cellsinflammationangiogenesisDiseases of the circulatory (Cardiovascular) systemRC666-701PhysiologyQP1-981ENVascular Biology, Vol 3, Iss 1, Pp R96-R105 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interleukins endothelial cells inflammation angiogenesis Diseases of the circulatory (Cardiovascular) system RC666-701 Physiology QP1-981
spellingShingle	interleukins endothelial cells inflammation angiogenesis Diseases of the circulatory (Cardiovascular) system RC666-701 Physiology QP1-981 Maria Luigia Carbone Cristina Maria Failla Interleukin role in the regulation of endothelial cell pathological activation
description	Interleukins (ILs) are the group of cytokines firstly identified as expressed by leukocytes and playing different immunomodulatory functions. With increasing evidence of a constant crosstalk between leukocytes and endothelial cells in the regulation of immune cell differentiation and activation, a role of ILs also in endothelial cell stimulation and vascular inflammation has been shown. ILs act on endothelial cells both in an autocrine and a paracrine manner. In fact, a cross regulation is present among ILs expressed by different cell types, leading to amplification or blocking of the initial inflammatory signal with the secretion of additional ILs or involvement of other adjacent cells and tissues. Based on selective structural features, ILs can be divided into four major groups, a fifth group comprises ILs that do not fit into any of the other four. Most of the ILs playing a role in endothelial cell activation belong to the IL1-like cytokine group, but the number of ILs involved in vascular inflammation is constantly growing, and a special contribution of IL6, IL8, and IL17 has been underlined. This review aims at presenting current knowledge and at underling missing information about the role of IL in activating endothelial cells in selected pathological settings such as tumours, psoriasis, systemic sclerosis, and viral infection.
format	article
author	Maria Luigia Carbone Cristina Maria Failla
author_facet	Maria Luigia Carbone Cristina Maria Failla
author_sort	Maria Luigia Carbone
title	Interleukin role in the regulation of endothelial cell pathological activation
title_short	Interleukin role in the regulation of endothelial cell pathological activation
title_full	Interleukin role in the regulation of endothelial cell pathological activation
title_fullStr	Interleukin role in the regulation of endothelial cell pathological activation
title_full_unstemmed	Interleukin role in the regulation of endothelial cell pathological activation
title_sort	interleukin role in the regulation of endothelial cell pathological activation
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/VB-21-0010 https://doaj.org/article/66aa131d9879485e9699e91444475108
work_keys_str_mv	AT marialuigiacarbone interleukinroleintheregulationofendothelialcellpathologicalactivation AT cristinamariafailla interleukinroleintheregulationofendothelialcellpathologicalactivation
_version_	1718426607431974912

Interleukin role in the regulation of endothelial cell pathological activation

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