Novel carbon quantum dots from egg yolk oil and their haemostatic effects

Abstract In this study, the properties of egg yolk oil (EYO) were investigated. Water extraction, dialysis, and ultrafiltration were used to extract and purify EYO, and microscopy, spectrophotometry, and chromatography were used to identify carbon dots (CDs) present in EYO (EYO CDs). Morphology anal...

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Autores principales:	Yan Zhao, Yue Zhang, Xiaoman Liu, Hui Kong, Yongzhi Wang, Gaofeng Qin, Peng Cao, Xingxing Song, Xin Yan, Qingguo Wang, Huihua Qu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66aa21a61b934f258280bf4852834728
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spelling	oai:doaj.org-article:66aa21a61b934f258280bf48528347282021-12-02T11:40:23ZNovel carbon quantum dots from egg yolk oil and their haemostatic effects10.1038/s41598-017-04073-12045-2322https://doaj.org/article/66aa21a61b934f258280bf48528347282017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04073-1https://doaj.org/toc/2045-2322Abstract In this study, the properties of egg yolk oil (EYO) were investigated. Water extraction, dialysis, and ultrafiltration were used to extract and purify EYO, and microscopy, spectrophotometry, and chromatography were used to identify carbon dots (CDs) present in EYO (EYO CDs). Morphology analyses demonstrated that CDs were almost spherical, with an average size of <10 nm, a lattice spacing of 0.267 nm, and a composition of mainly C, O, and Fe. The solution showed bright blue fluorescence at 365 nm. Tail haemorrhaging and liver haemorrhaging experiments showed that CD-treated mice had significantly shorter bleeding times than did control mice. Coagulation assays suggested that EYO CDs stimulate the intrinsic blood coagulation system and activate the fibrinogen system. Thus, EYO CDs possess the ability to activate haemostasis, which may lead to further investigations of this ingredient of traditional Chinese medicine.Yan ZhaoYue ZhangXiaoman LiuHui KongYongzhi WangGaofeng QinPeng CaoXingxing SongXin YanQingguo WangHuihua QuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Zhao Yue Zhang Xiaoman Liu Hui Kong Yongzhi Wang Gaofeng Qin Peng Cao Xingxing Song Xin Yan Qingguo Wang Huihua Qu Novel carbon quantum dots from egg yolk oil and their haemostatic effects
description	Abstract In this study, the properties of egg yolk oil (EYO) were investigated. Water extraction, dialysis, and ultrafiltration were used to extract and purify EYO, and microscopy, spectrophotometry, and chromatography were used to identify carbon dots (CDs) present in EYO (EYO CDs). Morphology analyses demonstrated that CDs were almost spherical, with an average size of <10 nm, a lattice spacing of 0.267 nm, and a composition of mainly C, O, and Fe. The solution showed bright blue fluorescence at 365 nm. Tail haemorrhaging and liver haemorrhaging experiments showed that CD-treated mice had significantly shorter bleeding times than did control mice. Coagulation assays suggested that EYO CDs stimulate the intrinsic blood coagulation system and activate the fibrinogen system. Thus, EYO CDs possess the ability to activate haemostasis, which may lead to further investigations of this ingredient of traditional Chinese medicine.
format	article
author	Yan Zhao Yue Zhang Xiaoman Liu Hui Kong Yongzhi Wang Gaofeng Qin Peng Cao Xingxing Song Xin Yan Qingguo Wang Huihua Qu
author_facet	Yan Zhao Yue Zhang Xiaoman Liu Hui Kong Yongzhi Wang Gaofeng Qin Peng Cao Xingxing Song Xin Yan Qingguo Wang Huihua Qu
author_sort	Yan Zhao
title	Novel carbon quantum dots from egg yolk oil and their haemostatic effects
title_short	Novel carbon quantum dots from egg yolk oil and their haemostatic effects
title_full	Novel carbon quantum dots from egg yolk oil and their haemostatic effects
title_fullStr	Novel carbon quantum dots from egg yolk oil and their haemostatic effects
title_full_unstemmed	Novel carbon quantum dots from egg yolk oil and their haemostatic effects
title_sort	novel carbon quantum dots from egg yolk oil and their haemostatic effects
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/66aa21a61b934f258280bf4852834728
work_keys_str_mv	AT yanzhao novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT yuezhang novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT xiaomanliu novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT huikong novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT yongzhiwang novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT gaofengqin novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT pengcao novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT xingxingsong novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT xinyan novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT qingguowang novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects AT huihuaqu novelcarbonquantumdotsfromeggyolkoilandtheirhaemostaticeffects
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Novel carbon quantum dots from egg yolk oil and their haemostatic effects

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