New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity

Spherical selenium-oxide and copper-oxide nanoparticles (SeO-NP with mean diameter 51 ± 14 nm and CuO-NP with mean diameter 21 ± 4 nm) were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence. Compared with SeO-NP, CuO-NP produced a somew...

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Autores principales:	Vladimir Panov, Tatiana Bushueva, Ilzira Minigalieva, Anna Naumova, Vladimir Shur, Ekaterina Shishkina, Marina Sutunkova, Vladimir Gurviсh, Larisa Privalova, Boris Katsnelson
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/66ad110772c54585ac1e35a2a73d34e4
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spelling	oai:doaj.org-article:66ad110772c54585ac1e35a2a73d34e42021-12-01T23:35:08ZNew Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity1559-325810.1177/15593258211052420https://doaj.org/article/66ad110772c54585ac1e35a2a73d34e42021-10-01T00:00:00Zhttps://doi.org/10.1177/15593258211052420https://doaj.org/toc/1559-3258Spherical selenium-oxide and copper-oxide nanoparticles (SeO-NP with mean diameter 51 ± 14 nm and CuO-NP with mean diameter 21 ± 4 nm) were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence. Compared with SeO-NP, CuO-NP produced a somewhat stronger effect of this kind. Along with cell hypertrophy developing in response to certain doses of SeO-NP and CuO-NP, our experiment also revealed doses causing a decrease in cell and cell-nucleus sizes. We observed both monotonic and different variants of nonmonotonic dose-response relationship. For the latter, we have succeeded in constructing adequate mathematical expressions based on the generalized hormesis paradigm that we had considered previously in respect of CdS-NP and PbS-NP cytotoxicity for cardiomyocites. It was demonstrated as well that combined toxicity of SeO-NP and CuO-NP is of different types depending on the outcome.Vladimir PanovTatiana BushuevaIlzira MinigalievaAnna NaumovaVladimir ShurEkaterina ShishkinaMarina SutunkovaVladimir GurviсhLarisa PrivalovaBoris KatsnelsonSAGE PublishingarticleTherapeutics. PharmacologyRM1-950ENDose-Response, Vol 19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Vladimir Panov Tatiana Bushueva Ilzira Minigalieva Anna Naumova Vladimir Shur Ekaterina Shishkina Marina Sutunkova Vladimir Gurviсh Larisa Privalova Boris Katsnelson New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity
description	Spherical selenium-oxide and copper-oxide nanoparticles (SeO-NP with mean diameter 51 ± 14 nm and CuO-NP with mean diameter 21 ± 4 nm) were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence. Compared with SeO-NP, CuO-NP produced a somewhat stronger effect of this kind. Along with cell hypertrophy developing in response to certain doses of SeO-NP and CuO-NP, our experiment also revealed doses causing a decrease in cell and cell-nucleus sizes. We observed both monotonic and different variants of nonmonotonic dose-response relationship. For the latter, we have succeeded in constructing adequate mathematical expressions based on the generalized hormesis paradigm that we had considered previously in respect of CdS-NP and PbS-NP cytotoxicity for cardiomyocites. It was demonstrated as well that combined toxicity of SeO-NP and CuO-NP is of different types depending on the outcome.
format	article
author	Vladimir Panov Tatiana Bushueva Ilzira Minigalieva Anna Naumova Vladimir Shur Ekaterina Shishkina Marina Sutunkova Vladimir Gurviсh Larisa Privalova Boris Katsnelson
author_facet	Vladimir Panov Tatiana Bushueva Ilzira Minigalieva Anna Naumova Vladimir Shur Ekaterina Shishkina Marina Sutunkova Vladimir Gurviсh Larisa Privalova Boris Katsnelson
author_sort	Vladimir Panov
title	New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity
title_short	New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity
title_full	New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity
title_fullStr	New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity
title_full_unstemmed	New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity
title_sort	new data on variously directed dose-response relationships and the combined action types for different outcomes of nanoparticle cytotoxicity
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/66ad110772c54585ac1e35a2a73d34e4
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New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity

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