Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.

MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 8...

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Autores principales:	Eric A Miska, Ezequiel Alvarez-Saavedra, Allison L Abbott, Nelson C Lau, Andrew B Hellman, Shannon M McGonagle, David P Bartel, Victor R Ambros, H Robert Horvitz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/66adfa1501d9497e90c6c7944b050fa3
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id	oai:doaj.org-article:66adfa1501d9497e90c6c7944b050fa3
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spelling	oai:doaj.org-article:66adfa1501d9497e90c6c7944b050fa32021-11-25T05:52:21ZMost Caenorhabditis elegans microRNAs are individually not essential for development or viability.1553-73901553-740410.1371/journal.pgen.0030215https://doaj.org/article/66adfa1501d9497e90c6c7944b050fa32007-12-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.0030215https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or development of C. elegans, and mutations in most miRNA genes do not result in grossly abnormal phenotypes. These observations are consistent with the hypothesis that there is significant functional redundancy among miRNAs or among gene pathways regulated by miRNAs. This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent resource for the systematic study of miRNAs.Eric A MiskaEzequiel Alvarez-SaavedraAllison L AbbottNelson C LauAndrew B HellmanShannon M McGonagleDavid P BartelVictor R AmbrosH Robert HorvitzPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 3, Iss 12, p e215 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Eric A Miska Ezequiel Alvarez-Saavedra Allison L Abbott Nelson C Lau Andrew B Hellman Shannon M McGonagle David P Bartel Victor R Ambros H Robert Horvitz Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
description	MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or development of C. elegans, and mutations in most miRNA genes do not result in grossly abnormal phenotypes. These observations are consistent with the hypothesis that there is significant functional redundancy among miRNAs or among gene pathways regulated by miRNAs. This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent resource for the systematic study of miRNAs.
format	article
author	Eric A Miska Ezequiel Alvarez-Saavedra Allison L Abbott Nelson C Lau Andrew B Hellman Shannon M McGonagle David P Bartel Victor R Ambros H Robert Horvitz
author_facet	Eric A Miska Ezequiel Alvarez-Saavedra Allison L Abbott Nelson C Lau Andrew B Hellman Shannon M McGonagle David P Bartel Victor R Ambros H Robert Horvitz
author_sort	Eric A Miska
title	Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
title_short	Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
title_full	Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
title_fullStr	Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
title_full_unstemmed	Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
title_sort	most caenorhabditis elegans micrornas are individually not essential for development or viability.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/66adfa1501d9497e90c6c7944b050fa3
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Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.

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