IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS

Abstract. Sixty-nine children (5 to 14 years old) with infectious mononucleosis caused by EBV were observed in acute phase and during recovery period. The indexes under study did evaluate cell-mediated and humoral immunity, levels of spontaneous and mitogen-induced production of IL-2, IL-10, IFNγ by...

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Autores principales:	L. M. Kurtasova, A. E. Golovanova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunity cytokines infectious mononucleosis il-2 il-10 ifnγ Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/66ae3526448640c3bc5d63b066555e65
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spelling	oai:doaj.org-article:66ae3526448640c3bc5d63b066555e652021-11-18T08:03:39ZIMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS1563-06252313-741X10.15789/1563-0625-2007-4-5-541-545https://doaj.org/article/66ae3526448640c3bc5d63b066555e652014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/238https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Sixty-nine children (5 to 14 years old) with infectious mononucleosis caused by EBV were observed in acute phase and during recovery period. The indexes under study did evaluate cell-mediated and humoral immunity, levels of spontaneous and mitogen-induced production of IL-2, IL-10, IFNγ by peripheral blood mononuclears. We have founded appropriate changes to be dependent on clinical phase of the disease. The most significant changes were revealed during acute phase of disease. A positive dynamics of cell-mediated and humoral immune response was observed during convalescence period. However, complete normalization of most immunologic indexes and cytokine status did not occur, corresponding to the clinical signs. This situation necessitates immune rehabilitation to be carried out for the children having at this phase of infectious mononucleosis.L. M. KurtasovaA. E. GolovanovaSPb RAACIarticleimmunitycytokinesinfectious mononucleosisil-2il-10ifnγImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 541-545 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunity cytokines infectious mononucleosis il-2 il-10 ifnγ Immunologic diseases. Allergy RC581-607
spellingShingle	immunity cytokines infectious mononucleosis il-2 il-10 ifnγ Immunologic diseases. Allergy RC581-607 L. M. Kurtasova A. E. Golovanova IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
description	Abstract. Sixty-nine children (5 to 14 years old) with infectious mononucleosis caused by EBV were observed in acute phase and during recovery period. The indexes under study did evaluate cell-mediated and humoral immunity, levels of spontaneous and mitogen-induced production of IL-2, IL-10, IFNγ by peripheral blood mononuclears. We have founded appropriate changes to be dependent on clinical phase of the disease. The most significant changes were revealed during acute phase of disease. A positive dynamics of cell-mediated and humoral immune response was observed during convalescence period. However, complete normalization of most immunologic indexes and cytokine status did not occur, corresponding to the clinical signs. This situation necessitates immune rehabilitation to be carried out for the children having at this phase of infectious mononucleosis.
format	article
author	L. M. Kurtasova A. E. Golovanova
author_facet	L. M. Kurtasova A. E. Golovanova
author_sort	L. M. Kurtasova
title	IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_short	IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_full	IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_fullStr	IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_full_unstemmed	IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_sort	immunological indexes and cytokine profile in the children during infectious mononucleosis caused by epstein-barr virus
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/66ae3526448640c3bc5d63b066555e65
work_keys_str_mv	AT lmkurtasova immunologicalindexesandcytokineprofileinthechildrenduringinfectiousmononucleosiscausedbyepsteinbarrvirus AT aegolovanova immunologicalindexesandcytokineprofileinthechildrenduringinfectiousmononucleosiscausedbyepsteinbarrvirus
_version_	1718422547637207040

IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS

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