Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.

<h4>Introduction</h4>Despite tight glycemic control, pregnancy complication rate in type 1 diabetes patients is higher than in normal pregnancy. Other etiological factors may be responsible for the development of adverse pregnancy outcome. Acceptance of the semi-allogeneic fetus is accom...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bart Groen, Thera P Links, Joop D Lefrandt, Paul P van den Berg, Paul de Vos, Marijke M Faas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66b081e1aec74d068c6f60845ace6e6c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:66b081e1aec74d068c6f60845ace6e6c
record_format	dspace
spelling	oai:doaj.org-article:66b081e1aec74d068c6f60845ace6e6c2021-11-18T07:40:43ZAberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.1932-620310.1371/journal.pone.0065490https://doaj.org/article/66b081e1aec74d068c6f60845ace6e6c2013-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0065490https://doaj.org/toc/1932-6203<h4>Introduction</h4>Despite tight glycemic control, pregnancy complication rate in type 1 diabetes patients is higher than in normal pregnancy. Other etiological factors may be responsible for the development of adverse pregnancy outcome. Acceptance of the semi-allogeneic fetus is accompanied by adaptations in the maternal immune-response. Maladaptations of the immune-response has been shown to contribute to pregnancy complications. We hypothesized that type 1 diabetes, as an autoimmune disease, may be associated with maladaptations of the immune-response to pregnancy, possibly resulting in pregnancy complications.<h4>Methods</h4>We studied pregnancy outcome and pregnancy-induced immunological adaptations in a normoglycemic rat-model of type 1 diabetes, i.e. biobreeding diabetes-prone rats (BBDP; 5 non-pregnant rats, 7 pregnant day 10 rats and 6 pregnant day 18 rats) , versus non-diabetic control rats (i.e. congenic non-diabetic biobreeding diabetes-resistant (BBDR; 6 non-pregnant rats, 6 pregnant day 10 rats and 6 pregnant day 18 rats) and Wistar-rats (6 non-pregnant, 6 pregnant day 10 rats and 5 pregnant day 18 rats)).<h4>Results</h4>We observed reduced litter size, lower fetal weight of viable fetuses and increased numbers of resorptions versus control rats. These complications are accompanied by various differences in the immune-response between BBDP and control rats in both pregnant and non-pregnant animals. The immune-response in non-pregnant BBDP-rats was characterized by decreased percentages of lymphocytes, increased percentages of effector T-cells, regulatory T-cells and natural killer cells, an increased Th1/Th2-ratio and activated monocytes versus Wistar and BBDR-rats. Furthermore, pregnancy-induced adaptations in BBDP-rats coincided with an increased Th1/Th2-ratio, a decreased mean fluorescence intensity CD161a/NKR-P1b ratio and no further activation of monocytes versus non-diabetic control rats.<h4>Conclusion</h4>This study suggests that even in the face of strict normoglycemia, pregnancy complications still occur in type 1 diabetic pregnancies. This adverse pregnancy outcome may be related to the aberrant immunological adaptations to pregnancy in diabetic rats.Bart GroenThera P LinksJoop D LefrandtPaul P van den BergPaul de VosMarijke M FaasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65490 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bart Groen Thera P Links Joop D Lefrandt Paul P van den Berg Paul de Vos Marijke M Faas Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.
description	<h4>Introduction</h4>Despite tight glycemic control, pregnancy complication rate in type 1 diabetes patients is higher than in normal pregnancy. Other etiological factors may be responsible for the development of adverse pregnancy outcome. Acceptance of the semi-allogeneic fetus is accompanied by adaptations in the maternal immune-response. Maladaptations of the immune-response has been shown to contribute to pregnancy complications. We hypothesized that type 1 diabetes, as an autoimmune disease, may be associated with maladaptations of the immune-response to pregnancy, possibly resulting in pregnancy complications.<h4>Methods</h4>We studied pregnancy outcome and pregnancy-induced immunological adaptations in a normoglycemic rat-model of type 1 diabetes, i.e. biobreeding diabetes-prone rats (BBDP; 5 non-pregnant rats, 7 pregnant day 10 rats and 6 pregnant day 18 rats) , versus non-diabetic control rats (i.e. congenic non-diabetic biobreeding diabetes-resistant (BBDR; 6 non-pregnant rats, 6 pregnant day 10 rats and 6 pregnant day 18 rats) and Wistar-rats (6 non-pregnant, 6 pregnant day 10 rats and 5 pregnant day 18 rats)).<h4>Results</h4>We observed reduced litter size, lower fetal weight of viable fetuses and increased numbers of resorptions versus control rats. These complications are accompanied by various differences in the immune-response between BBDP and control rats in both pregnant and non-pregnant animals. The immune-response in non-pregnant BBDP-rats was characterized by decreased percentages of lymphocytes, increased percentages of effector T-cells, regulatory T-cells and natural killer cells, an increased Th1/Th2-ratio and activated monocytes versus Wistar and BBDR-rats. Furthermore, pregnancy-induced adaptations in BBDP-rats coincided with an increased Th1/Th2-ratio, a decreased mean fluorescence intensity CD161a/NKR-P1b ratio and no further activation of monocytes versus non-diabetic control rats.<h4>Conclusion</h4>This study suggests that even in the face of strict normoglycemia, pregnancy complications still occur in type 1 diabetic pregnancies. This adverse pregnancy outcome may be related to the aberrant immunological adaptations to pregnancy in diabetic rats.
format	article
author	Bart Groen Thera P Links Joop D Lefrandt Paul P van den Berg Paul de Vos Marijke M Faas
author_facet	Bart Groen Thera P Links Joop D Lefrandt Paul P van den Berg Paul de Vos Marijke M Faas
author_sort	Bart Groen
title	Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.
title_short	Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.
title_full	Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.
title_fullStr	Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.
title_full_unstemmed	Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.
title_sort	aberrant pregnancy adaptations in the peripheral immune response in type 1 diabetes: a rat model.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/66b081e1aec74d068c6f60845ace6e6c
work_keys_str_mv	AT bartgroen aberrantpregnancyadaptationsintheperipheralimmuneresponseintype1diabetesaratmodel AT theraplinks aberrantpregnancyadaptationsintheperipheralimmuneresponseintype1diabetesaratmodel AT joopdlefrandt aberrantpregnancyadaptationsintheperipheralimmuneresponseintype1diabetesaratmodel AT paulpvandenberg aberrantpregnancyadaptationsintheperipheralimmuneresponseintype1diabetesaratmodel AT pauldevos aberrantpregnancyadaptationsintheperipheralimmuneresponseintype1diabetesaratmodel AT marijkemfaas aberrantpregnancyadaptationsintheperipheralimmuneresponseintype1diabetesaratmodel
_version_	1718423101416407040

Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.

Ejemplares similares