Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

Here, using cryo-EM and smFRET, Henderson et al. show how tryptophan 571 in the HIV-1 Env acts as a conformational switch during receptor-mediated viral entry and design HIV-1 Env proteins that cannot undergo conformational changes. This has important implications for HIV-1 vaccine design.

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Autores principales:	Rory Henderson, Maolin Lu, Ye Zhou, Zekun Mu, Robert Parks, Qifeng Han, Allen L. Hsu, Elizabeth Carter, Scott C. Blanchard, R J Edwards, Kevin Wiehe, Kevin O. Saunders, Mario J. Borgnia, Alberto Bartesaghi, Walther Mothes, Barton F. Haynes, Priyamvada Acharya, S. Munir Alam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66b0bc924f5e41b8ab9751e365c7c967
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spelling	oai:doaj.org-article:66b0bc924f5e41b8ab9751e365c7c9672021-12-02T17:31:10ZDisruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements10.1038/s41467-019-14196-w2041-1723https://doaj.org/article/66b0bc924f5e41b8ab9751e365c7c9672020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14196-whttps://doaj.org/toc/2041-1723Here, using cryo-EM and smFRET, Henderson et al. show how tryptophan 571 in the HIV-1 Env acts as a conformational switch during receptor-mediated viral entry and design HIV-1 Env proteins that cannot undergo conformational changes. This has important implications for HIV-1 vaccine design.Rory HendersonMaolin LuYe ZhouZekun MuRobert ParksQifeng HanAllen L. HsuElizabeth CarterScott C. BlanchardR J EdwardsKevin WieheKevin O. SaundersMario J. BorgniaAlberto BartesaghiWalther MothesBarton F. HaynesPriyamvada AcharyaS. Munir AlamNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rory Henderson Maolin Lu Ye Zhou Zekun Mu Robert Parks Qifeng Han Allen L. Hsu Elizabeth Carter Scott C. Blanchard R J Edwards Kevin Wiehe Kevin O. Saunders Mario J. Borgnia Alberto Bartesaghi Walther Mothes Barton F. Haynes Priyamvada Acharya S. Munir Alam Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
description	Here, using cryo-EM and smFRET, Henderson et al. show how tryptophan 571 in the HIV-1 Env acts as a conformational switch during receptor-mediated viral entry and design HIV-1 Env proteins that cannot undergo conformational changes. This has important implications for HIV-1 vaccine design.
format	article
author	Rory Henderson Maolin Lu Ye Zhou Zekun Mu Robert Parks Qifeng Han Allen L. Hsu Elizabeth Carter Scott C. Blanchard R J Edwards Kevin Wiehe Kevin O. Saunders Mario J. Borgnia Alberto Bartesaghi Walther Mothes Barton F. Haynes Priyamvada Acharya S. Munir Alam
author_facet	Rory Henderson Maolin Lu Ye Zhou Zekun Mu Robert Parks Qifeng Han Allen L. Hsu Elizabeth Carter Scott C. Blanchard R J Edwards Kevin Wiehe Kevin O. Saunders Mario J. Borgnia Alberto Bartesaghi Walther Mothes Barton F. Haynes Priyamvada Acharya S. Munir Alam
author_sort	Rory Henderson
title	Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
title_short	Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
title_full	Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
title_fullStr	Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
title_full_unstemmed	Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
title_sort	disruption of the hiv-1 envelope allosteric network blocks cd4-induced rearrangements
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/66b0bc924f5e41b8ab9751e365c7c967
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Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

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