Caesarean delivery is associated with increased blood pressure in young adult offspring

Abstract We examined the associations between caesarean section (CS) delivery and cardiovascular risk factors in young adults in Thailand. Participants were 632 offspring from a birth cohort in Chiang Mai (Northern Thailand), born in 1989–1990 and assessed in 2010 at a mean age of 20.6 years, includ...

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Autores principales:	Amaraporn Rerkasem, Sarah E. Maessen, Antika Wongthanee, Sakda Pruenglampoo, Ampica Mangklabruks, Patumrat Sripan, José G. B. Derraik, Kittipan Rerkasem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66b1de7cfde04d20a60c730f626230a8
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spelling	oai:doaj.org-article:66b1de7cfde04d20a60c730f626230a82021-12-02T15:55:18ZCaesarean delivery is associated with increased blood pressure in young adult offspring10.1038/s41598-021-89438-32045-2322https://doaj.org/article/66b1de7cfde04d20a60c730f626230a82021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89438-3https://doaj.org/toc/2045-2322Abstract We examined the associations between caesarean section (CS) delivery and cardiovascular risk factors in young adults in Thailand. Participants were 632 offspring from a birth cohort in Chiang Mai (Northern Thailand), born in 1989–1990 and assessed in 2010 at a mean age of 20.6 years, including 57 individuals (9.0%) born by CS and 575 born vaginally. Clinical assessments included anthropometry, blood pressure (BP), carotid intima-media thickness, and fasting blood glucose, insulin, and lipid profile. Young adults born by CS had systolic BP (SBP) 6.2 mmHg higher (p < 0.001), diastolic BP 3.2 mmHg higher (p = 0.029), and mean arterial pressure (MAP) 4.1 mmHg higher (p = 0.003) than those born vaginally. After covariate adjustments, SBP and MAP remained 4.1 mmHg (p = 0.006) and 2.9 mmHg (p = 0.021) higher, respectively, in the CS group. The prevalence of abnormal SBP (i.e., pre-hypertension or hypertension) in the CS group was 2.5 times that of those born vaginally (25.0% vs 10.3%; p = 0.003), with an adjusted relative risk of abnormal SBP 1.9 times higher (95% CI 1.15, 2.98; p = 0.011). There were no differences in anthropometry (including obesity risk) or other metabolic parameters. In this birth cohort in Thailand, CS delivery was associated with increased blood pressure in young adulthood.Amaraporn RerkasemSarah E. MaessenAntika WongthaneeSakda PruenglampooAmpica MangklabruksPatumrat SripanJosé G. B. DerraikKittipan RerkasemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amaraporn Rerkasem Sarah E. Maessen Antika Wongthanee Sakda Pruenglampoo Ampica Mangklabruks Patumrat Sripan José G. B. Derraik Kittipan Rerkasem Caesarean delivery is associated with increased blood pressure in young adult offspring
description	Abstract We examined the associations between caesarean section (CS) delivery and cardiovascular risk factors in young adults in Thailand. Participants were 632 offspring from a birth cohort in Chiang Mai (Northern Thailand), born in 1989–1990 and assessed in 2010 at a mean age of 20.6 years, including 57 individuals (9.0%) born by CS and 575 born vaginally. Clinical assessments included anthropometry, blood pressure (BP), carotid intima-media thickness, and fasting blood glucose, insulin, and lipid profile. Young adults born by CS had systolic BP (SBP) 6.2 mmHg higher (p < 0.001), diastolic BP 3.2 mmHg higher (p = 0.029), and mean arterial pressure (MAP) 4.1 mmHg higher (p = 0.003) than those born vaginally. After covariate adjustments, SBP and MAP remained 4.1 mmHg (p = 0.006) and 2.9 mmHg (p = 0.021) higher, respectively, in the CS group. The prevalence of abnormal SBP (i.e., pre-hypertension or hypertension) in the CS group was 2.5 times that of those born vaginally (25.0% vs 10.3%; p = 0.003), with an adjusted relative risk of abnormal SBP 1.9 times higher (95% CI 1.15, 2.98; p = 0.011). There were no differences in anthropometry (including obesity risk) or other metabolic parameters. In this birth cohort in Thailand, CS delivery was associated with increased blood pressure in young adulthood.
format	article
author	Amaraporn Rerkasem Sarah E. Maessen Antika Wongthanee Sakda Pruenglampoo Ampica Mangklabruks Patumrat Sripan José G. B. Derraik Kittipan Rerkasem
author_facet	Amaraporn Rerkasem Sarah E. Maessen Antika Wongthanee Sakda Pruenglampoo Ampica Mangklabruks Patumrat Sripan José G. B. Derraik Kittipan Rerkasem
author_sort	Amaraporn Rerkasem
title	Caesarean delivery is associated with increased blood pressure in young adult offspring
title_short	Caesarean delivery is associated with increased blood pressure in young adult offspring
title_full	Caesarean delivery is associated with increased blood pressure in young adult offspring
title_fullStr	Caesarean delivery is associated with increased blood pressure in young adult offspring
title_full_unstemmed	Caesarean delivery is associated with increased blood pressure in young adult offspring
title_sort	caesarean delivery is associated with increased blood pressure in young adult offspring
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66b1de7cfde04d20a60c730f626230a8
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Caesarean delivery is associated with increased blood pressure in young adult offspring

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