Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collage...

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Autores principales:	Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips, Jonathan M. Kurie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66b3577e6b604e7983c92825500bf879
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spelling	oai:doaj.org-article:66b3577e6b604e7983c92825500bf8792021-12-02T14:40:08ZPro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding10.1038/s41467-018-02859-z2041-1723https://doaj.org/article/66b3577e6b604e7983c92825500bf8792018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02859-zhttps://doaj.org/toc/2041-1723Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.Hou-Fu GuoChi-Lin TsaiMasahiko TerajimaXiaochao TanPriyam BanerjeeMitchell D. MillerXin LiuJiang YuJovita ByemerwaSarah AlvaradoTamer S. KaoudKevin N. DalbyNeus Bota-RabassedasYulong ChenMitsuo YamauchiJohn A. TainerGeorge N. PhillipsJonathan M. KurieNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hou-Fu Guo Chi-Lin Tsai Masahiko Terajima Xiaochao Tan Priyam Banerjee Mitchell D. Miller Xin Liu Jiang Yu Jovita Byemerwa Sarah Alvarado Tamer S. Kaoud Kevin N. Dalby Neus Bota-Rabassedas Yulong Chen Mitsuo Yamauchi John A. Tainer George N. Phillips Jonathan M. Kurie Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
description	Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.
format	article
author	Hou-Fu Guo Chi-Lin Tsai Masahiko Terajima Xiaochao Tan Priyam Banerjee Mitchell D. Miller Xin Liu Jiang Yu Jovita Byemerwa Sarah Alvarado Tamer S. Kaoud Kevin N. Dalby Neus Bota-Rabassedas Yulong Chen Mitsuo Yamauchi John A. Tainer George N. Phillips Jonathan M. Kurie
author_facet	Hou-Fu Guo Chi-Lin Tsai Masahiko Terajima Xiaochao Tan Priyam Banerjee Mitchell D. Miller Xin Liu Jiang Yu Jovita Byemerwa Sarah Alvarado Tamer S. Kaoud Kevin N. Dalby Neus Bota-Rabassedas Yulong Chen Mitsuo Yamauchi John A. Tainer George N. Phillips Jonathan M. Kurie
author_sort	Hou-Fu Guo
title	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
title_short	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
title_full	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
title_fullStr	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
title_full_unstemmed	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
title_sort	pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by fe2+-binding
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/66b3577e6b604e7983c92825500bf879
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Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

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