The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.

The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.

Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion. We previously demonstrated that in epithelial cells activation of DGKα activity promotes cytoskeletal remodeling and matrix invasion by recruiti...

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Main Authors: Elena Rainero, Cristina Cianflone, Paolo Ettore Porporato, Federica Chianale, Valeria Malacarne, Valentina Bettio, Elisa Ruffo, Michele Ferrara, Fabio Benecchia, Daniela Capello, Wolfgang Paster, Irene Locatelli, Alessandra Bertoni, Nicoletta Filigheddu, Fabiola Sinigaglia, Jim C Norman, Gianluca Baldanzi, Andrea Graziani
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/66b47552bef645f1b45c28e4c5ca2e51
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