Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.

<h4>Introduction</h4>Maternal Cytomegalovirus (CMV) infection in the first trimester (T1) of pregnancy is a public health concern, as it increases the risk of severe neurodevelopmental outcomes associated with congenital infection compared to infections occurring later during pregnancy.&...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Safari Joseph Balegamire, Christian Renaud, Benoît Mâsse, Kate Zinszer, Soren Gantt, Yves Giguere, Jean-Claude Forest, Isabelle Boucoiran
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66b78e8b07b84755a52e4628602db944
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:66b78e8b07b84755a52e4628602db944
record_format	dspace
spelling	oai:doaj.org-article:66b78e8b07b84755a52e4628602db9442021-12-02T20:03:50ZFrequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.1932-620310.1371/journal.pone.0252309https://doaj.org/article/66b78e8b07b84755a52e4628602db9442021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252309https://doaj.org/toc/1932-6203<h4>Introduction</h4>Maternal Cytomegalovirus (CMV) infection in the first trimester (T1) of pregnancy is a public health concern, as it increases the risk of severe neurodevelopmental outcomes associated with congenital infection compared to infections occurring later during pregnancy.<h4>Objectives</h4>To determine CMV seroprevalence in T1 of pregnancy, its trend, risk factors and the incidence rate of primary infection during pregnancy.<h4>Methods</h4>Using the biobank of the prospective cohort "Grossesse en Santé de Québec" collected between April 2005 and March 2010 at the Québec-Laval Hospital, Québec, Canada, maternal CMV serology was determined using Abbott Architect Chemiluminescence microparticle immunoassays for immunoglobulin G(IgG), immunoglobulin M(IgM) titration and IgG avidity testing. Changepoint detection analysis was used to assess temporal trends. Risk factors associated with seropositivity were determined by multivariable logistic regression.<h4>Results</h4>CMV seroprevalence in T1 of pregnancy was 23.4% (965/4111, 95% CI, 22.1-24.7%). The incidence rate for CMV primary infection during pregnancy was 1.8 (95% CI, 1.2-2.6) per 100 person-years. No changepoint was identified in the maternal CMV-seroprevalence trend. Multivariable analyses showed that T1 maternal CMV seropositivity was associated with having one child OR 1.3 (95% CI, 1.10-1.73) or two or more children OR 1.5 (95%CI, 1.1-2.1), ethnicity other than Caucasian OR 2.1 (95% CI, 1.1-3.8) and country of birth other than Canada and the USA OR 2.8 (95% CI, 1.5-4.9).<h4>Conclusions</h4>In this cohort, maternal seroprevalence in T1 of pregnancy and seroconversion rate were low. This information and identified risk factors could help guide the development and implementation of preventive actions and evidence-based health policies to prevent CMV infection during pregnancy.Safari Joseph BalegamireChristian RenaudBenoît MâsseKate ZinszerSoren GanttYves GiguereJean-Claude ForestIsabelle BoucoiranPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252309 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Safari Joseph Balegamire Christian Renaud Benoît Mâsse Kate Zinszer Soren Gantt Yves Giguere Jean-Claude Forest Isabelle Boucoiran Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.
description	<h4>Introduction</h4>Maternal Cytomegalovirus (CMV) infection in the first trimester (T1) of pregnancy is a public health concern, as it increases the risk of severe neurodevelopmental outcomes associated with congenital infection compared to infections occurring later during pregnancy.<h4>Objectives</h4>To determine CMV seroprevalence in T1 of pregnancy, its trend, risk factors and the incidence rate of primary infection during pregnancy.<h4>Methods</h4>Using the biobank of the prospective cohort "Grossesse en Santé de Québec" collected between April 2005 and March 2010 at the Québec-Laval Hospital, Québec, Canada, maternal CMV serology was determined using Abbott Architect Chemiluminescence microparticle immunoassays for immunoglobulin G(IgG), immunoglobulin M(IgM) titration and IgG avidity testing. Changepoint detection analysis was used to assess temporal trends. Risk factors associated with seropositivity were determined by multivariable logistic regression.<h4>Results</h4>CMV seroprevalence in T1 of pregnancy was 23.4% (965/4111, 95% CI, 22.1-24.7%). The incidence rate for CMV primary infection during pregnancy was 1.8 (95% CI, 1.2-2.6) per 100 person-years. No changepoint was identified in the maternal CMV-seroprevalence trend. Multivariable analyses showed that T1 maternal CMV seropositivity was associated with having one child OR 1.3 (95% CI, 1.10-1.73) or two or more children OR 1.5 (95%CI, 1.1-2.1), ethnicity other than Caucasian OR 2.1 (95% CI, 1.1-3.8) and country of birth other than Canada and the USA OR 2.8 (95% CI, 1.5-4.9).<h4>Conclusions</h4>In this cohort, maternal seroprevalence in T1 of pregnancy and seroconversion rate were low. This information and identified risk factors could help guide the development and implementation of preventive actions and evidence-based health policies to prevent CMV infection during pregnancy.
format	article
author	Safari Joseph Balegamire Christian Renaud Benoît Mâsse Kate Zinszer Soren Gantt Yves Giguere Jean-Claude Forest Isabelle Boucoiran
author_facet	Safari Joseph Balegamire Christian Renaud Benoît Mâsse Kate Zinszer Soren Gantt Yves Giguere Jean-Claude Forest Isabelle Boucoiran
author_sort	Safari Joseph Balegamire
title	Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.
title_short	Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.
title_full	Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.
title_fullStr	Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.
title_full_unstemmed	Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.
title_sort	frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in quebec.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/66b78e8b07b84755a52e4628602db944
work_keys_str_mv	AT safarijosephbalegamire frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec AT christianrenaud frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec AT benoitmasse frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec AT katezinszer frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec AT sorengantt frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec AT yvesgiguere frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec AT jeanclaudeforest frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec AT isabelleboucoiran frequencytimingandriskfactorsforprimarymaternalcytomegalovirusinfectionduringpregnancyinquebec
_version_	1718375664679124992

Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec.

Ejemplares similares