Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans

The rapidly and constantly evolving coronavirus, SARS-CoV-2, imposes a great threat to human health causing severe lung disease and significant mortality. Cytoplasmic stress granules (SGs) exert anti-viral activities due to their involvement in translation inhibition and innate immune signaling. SAR...

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Autores principales:	Kartikay Prasad, Abdullah F. Alasmari, Nemat Ali, Rehan Khan, Adel Alghamdi, Vijay Kumar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 stress granule proteins protein–protein interaction network drug miRNAs Medicine R
Acceso en línea:	https://doaj.org/article/66b87f03e3a241aea881c65ba56e76a2
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spelling	oai:doaj.org-article:66b87f03e3a241aea881c65ba56e76a22021-11-25T18:38:25ZInsights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans10.3390/pathogens101114592076-0817https://doaj.org/article/66b87f03e3a241aea881c65ba56e76a22021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1459https://doaj.org/toc/2076-0817The rapidly and constantly evolving coronavirus, SARS-CoV-2, imposes a great threat to human health causing severe lung disease and significant mortality. Cytoplasmic stress granules (SGs) exert anti-viral activities due to their involvement in translation inhibition and innate immune signaling. SARS-CoV-2 sequesters important SG nucleator proteins and impairs SG formation, thus evading the host response for efficient viral replication. However, the significance of SGs in COVID-19 infection remains elusive. In this study, we utilize a protein-protein interaction network approach to systematically dissect the crosstalk of human post-translational regulatory networks governed by SG proteins due to SARS-CoV-2 infection. We uncovered that 116 human SG proteins directly interact with SARS-CoV-2 proteins and are involved in 430 different brain disorders including COVID-19. Further, we performed gene set enrichment analysis to identify the drugs against three important key SG proteins (DYNC1H1, DCTN1, and LMNA) and also looked for potential microRNAs (miRNAs) targeting these proteins. We identified bexarotene as a potential drug molecule and miRNAs, hsa-miR-615-3p, hsa-miR-221-3p, and hsa-miR-124-3p as potential candidates for the treatment of COVID-19 and associated manifestations.Kartikay PrasadAbdullah F. AlasmariNemat AliRehan KhanAdel AlghamdiVijay KumarMDPI AGarticleSARS-CoV-2stress granule proteinsprotein–protein interactionnetworkdrugmiRNAsMedicineRENPathogens, Vol 10, Iss 1459, p 1459 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 stress granule proteins protein–protein interaction network drug miRNAs Medicine R
spellingShingle	SARS-CoV-2 stress granule proteins protein–protein interaction network drug miRNAs Medicine R Kartikay Prasad Abdullah F. Alasmari Nemat Ali Rehan Khan Adel Alghamdi Vijay Kumar Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans
description	The rapidly and constantly evolving coronavirus, SARS-CoV-2, imposes a great threat to human health causing severe lung disease and significant mortality. Cytoplasmic stress granules (SGs) exert anti-viral activities due to their involvement in translation inhibition and innate immune signaling. SARS-CoV-2 sequesters important SG nucleator proteins and impairs SG formation, thus evading the host response for efficient viral replication. However, the significance of SGs in COVID-19 infection remains elusive. In this study, we utilize a protein-protein interaction network approach to systematically dissect the crosstalk of human post-translational regulatory networks governed by SG proteins due to SARS-CoV-2 infection. We uncovered that 116 human SG proteins directly interact with SARS-CoV-2 proteins and are involved in 430 different brain disorders including COVID-19. Further, we performed gene set enrichment analysis to identify the drugs against three important key SG proteins (DYNC1H1, DCTN1, and LMNA) and also looked for potential microRNAs (miRNAs) targeting these proteins. We identified bexarotene as a potential drug molecule and miRNAs, hsa-miR-615-3p, hsa-miR-221-3p, and hsa-miR-124-3p as potential candidates for the treatment of COVID-19 and associated manifestations.
format	article
author	Kartikay Prasad Abdullah F. Alasmari Nemat Ali Rehan Khan Adel Alghamdi Vijay Kumar
author_facet	Kartikay Prasad Abdullah F. Alasmari Nemat Ali Rehan Khan Adel Alghamdi Vijay Kumar
author_sort	Kartikay Prasad
title	Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans
title_short	Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans
title_full	Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans
title_fullStr	Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans
title_full_unstemmed	Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans
title_sort	insights into the sars-cov-2-mediated alteration in the stress granule protein regulatory networks in humans
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/66b87f03e3a241aea881c65ba56e76a2
work_keys_str_mv	AT kartikayprasad insightsintothesarscov2mediatedalterationinthestressgranuleproteinregulatorynetworksinhumans AT abdullahfalasmari insightsintothesarscov2mediatedalterationinthestressgranuleproteinregulatorynetworksinhumans AT nematali insightsintothesarscov2mediatedalterationinthestressgranuleproteinregulatorynetworksinhumans AT rehankhan insightsintothesarscov2mediatedalterationinthestressgranuleproteinregulatorynetworksinhumans AT adelalghamdi insightsintothesarscov2mediatedalterationinthestressgranuleproteinregulatorynetworksinhumans AT vijaykumar insightsintothesarscov2mediatedalterationinthestressgranuleproteinregulatorynetworksinhumans
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Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans

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