Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

Abstract Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level of risk it poses. Optical coherence...

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Autores principales:	Min Woo Lee, Joon Woo Song, Woo Jae Kang, Hyeong Soo Nam, Tae Shik Kim, Sunwon Kim, Wang-Yuhl Oh, Jin Won Kim, Hongki Yoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Fluorescence Lifetime Imaging (FLIm) Imaging Catheter FLIm Images Longer Fluorescence Normal Aorta Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66bd08a94edb44b28f777f2e95ef839c
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spelling	oai:doaj.org-article:66bd08a94edb44b28f777f2e95ef839c2021-12-02T15:07:46ZComprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging10.1038/s41598-018-32951-92045-2322https://doaj.org/article/66bd08a94edb44b28f777f2e95ef839c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32951-9https://doaj.org/toc/2045-2322Abstract Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular imaging device, including a custom-built OCT/FLIm system, a hybrid optical rotary joint, and an imaging catheter, to visualize the structure and biochemical composition of the plaque in an atherosclerotic rabbit artery in vivo. Especially, the autofluorescence lifetime of the endogenous tissue molecules can be used to characterize the biochemical composition; thus no exogenous contrast agent is required. Also, the physical properties of the imaging catheter and the imaging procedures are similar to those already used clinically, facilitating rapid translation into clinical use. This new intravascular imaging catheter can open up new opportunities for clinicians and researchers to investigate and diagnose coronary artery disease by simultaneously providing tissue microstructure and biochemical composition data in vivo without the use of exogenous contrast agent.Min Woo LeeJoon Woo SongWoo Jae KangHyeong Soo NamTae Shik KimSunwon KimWang-Yuhl OhJin Won KimHongki YooNature PortfolioarticleFluorescence Lifetime Imaging (FLIm)Imaging CatheterFLIm ImagesLonger FluorescenceNormal AortaMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fluorescence Lifetime Imaging (FLIm) Imaging Catheter FLIm Images Longer Fluorescence Normal Aorta Medicine R Science Q
spellingShingle	Fluorescence Lifetime Imaging (FLIm) Imaging Catheter FLIm Images Longer Fluorescence Normal Aorta Medicine R Science Q Min Woo Lee Joon Woo Song Woo Jae Kang Hyeong Soo Nam Tae Shik Kim Sunwon Kim Wang-Yuhl Oh Jin Won Kim Hongki Yoo Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
description	Abstract Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular imaging device, including a custom-built OCT/FLIm system, a hybrid optical rotary joint, and an imaging catheter, to visualize the structure and biochemical composition of the plaque in an atherosclerotic rabbit artery in vivo. Especially, the autofluorescence lifetime of the endogenous tissue molecules can be used to characterize the biochemical composition; thus no exogenous contrast agent is required. Also, the physical properties of the imaging catheter and the imaging procedures are similar to those already used clinically, facilitating rapid translation into clinical use. This new intravascular imaging catheter can open up new opportunities for clinicians and researchers to investigate and diagnose coronary artery disease by simultaneously providing tissue microstructure and biochemical composition data in vivo without the use of exogenous contrast agent.
format	article
author	Min Woo Lee Joon Woo Song Woo Jae Kang Hyeong Soo Nam Tae Shik Kim Sunwon Kim Wang-Yuhl Oh Jin Won Kim Hongki Yoo
author_facet	Min Woo Lee Joon Woo Song Woo Jae Kang Hyeong Soo Nam Tae Shik Kim Sunwon Kim Wang-Yuhl Oh Jin Won Kim Hongki Yoo
author_sort	Min Woo Lee
title	Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
title_short	Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
title_full	Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
title_fullStr	Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
title_full_unstemmed	Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
title_sort	comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/66bd08a94edb44b28f777f2e95ef839c
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Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

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