The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.

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Autores principales: Robert Verity, Ozkan Aydemir, Nicholas F. Brazeau, Oliver J. Watson, Nicholas J. Hathaway, Melchior Kashamuka Mwandagalirwa, Patrick W. Marsh, Kyaw Thwai, Travis Fulton, Madeline Denton, Andrew P. Morgan, Jonathan B. Parr, Patrick K. Tumwebaze, Melissa Conrad, Philip J. Rosenthal, Deus S. Ishengoma, Jeremiah Ngondi, Julie Gutman, Modest Mulenga, Douglas E. Norris, William J. Moss, Benedicta A. Mensah, James L. Myers-Hansen, Anita Ghansah, Antoinette K. Tshefu, Azra C. Ghani, Steven R. Meshnick, Jeffrey A. Bailey, Jonathan J. Juliano
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/66be251847414c22986caeb0cfc8324e
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spelling oai:doaj.org-article:66be251847414c22986caeb0cfc8324e2021-12-02T15:33:50ZThe impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC10.1038/s41467-020-15779-82041-1723https://doaj.org/article/66be251847414c22986caeb0cfc8324e2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15779-8https://doaj.org/toc/2041-1723The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.Robert VerityOzkan AydemirNicholas F. BrazeauOliver J. WatsonNicholas J. HathawayMelchior Kashamuka MwandagalirwaPatrick W. MarshKyaw ThwaiTravis FultonMadeline DentonAndrew P. MorganJonathan B. ParrPatrick K. TumwebazeMelissa ConradPhilip J. RosenthalDeus S. IshengomaJeremiah NgondiJulie GutmanModest MulengaDouglas E. NorrisWilliam J. MossBenedicta A. MensahJames L. Myers-HansenAnita GhansahAntoinette K. TshefuAzra C. GhaniSteven R. MeshnickJeffrey A. BaileyJonathan J. JulianoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Robert Verity
Ozkan Aydemir
Nicholas F. Brazeau
Oliver J. Watson
Nicholas J. Hathaway
Melchior Kashamuka Mwandagalirwa
Patrick W. Marsh
Kyaw Thwai
Travis Fulton
Madeline Denton
Andrew P. Morgan
Jonathan B. Parr
Patrick K. Tumwebaze
Melissa Conrad
Philip J. Rosenthal
Deus S. Ishengoma
Jeremiah Ngondi
Julie Gutman
Modest Mulenga
Douglas E. Norris
William J. Moss
Benedicta A. Mensah
James L. Myers-Hansen
Anita Ghansah
Antoinette K. Tshefu
Azra C. Ghani
Steven R. Meshnick
Jeffrey A. Bailey
Jonathan J. Juliano
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
description The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.
format article
author Robert Verity
Ozkan Aydemir
Nicholas F. Brazeau
Oliver J. Watson
Nicholas J. Hathaway
Melchior Kashamuka Mwandagalirwa
Patrick W. Marsh
Kyaw Thwai
Travis Fulton
Madeline Denton
Andrew P. Morgan
Jonathan B. Parr
Patrick K. Tumwebaze
Melissa Conrad
Philip J. Rosenthal
Deus S. Ishengoma
Jeremiah Ngondi
Julie Gutman
Modest Mulenga
Douglas E. Norris
William J. Moss
Benedicta A. Mensah
James L. Myers-Hansen
Anita Ghansah
Antoinette K. Tshefu
Azra C. Ghani
Steven R. Meshnick
Jeffrey A. Bailey
Jonathan J. Juliano
author_facet Robert Verity
Ozkan Aydemir
Nicholas F. Brazeau
Oliver J. Watson
Nicholas J. Hathaway
Melchior Kashamuka Mwandagalirwa
Patrick W. Marsh
Kyaw Thwai
Travis Fulton
Madeline Denton
Andrew P. Morgan
Jonathan B. Parr
Patrick K. Tumwebaze
Melissa Conrad
Philip J. Rosenthal
Deus S. Ishengoma
Jeremiah Ngondi
Julie Gutman
Modest Mulenga
Douglas E. Norris
William J. Moss
Benedicta A. Mensah
James L. Myers-Hansen
Anita Ghansah
Antoinette K. Tshefu
Azra C. Ghani
Steven R. Meshnick
Jeffrey A. Bailey
Jonathan J. Juliano
author_sort Robert Verity
title The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
title_short The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
title_full The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
title_fullStr The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
title_full_unstemmed The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
title_sort impact of antimalarial resistance on the genetic structure of plasmodium falciparum in the drc
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/66be251847414c22986caeb0cfc8324e
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