Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Biruk Bayleyegn,1 Berhanu Woldu,1 Aregawi Yalew,1 Desie Kasew,2 Fikir Asrie1 1Department of Hematology and Immunohematology, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia; 2Department of Medical Microbiology, College of Medicine and Health Science, University of Gond...

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Autores principales:	Bayleyegn B, Woldu B, Yalew A, Kasew D, Asrie F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	intestinal parasite hiv children ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/66bfb7ebc4ac420485a3bd26a3e85e96
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spelling	oai:doaj.org-article:66bfb7ebc4ac420485a3bd26a3e85e962021-12-02T14:08:52ZPrevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia1179-1373https://doaj.org/article/66bfb7ebc4ac420485a3bd26a3e85e962021-01-01T00:00:00Zhttps://www.dovepress.com/prevalence-of-intestinal-parasitic-infection-and-associated-factors-am-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Biruk Bayleyegn,1 Berhanu Woldu,1 Aregawi Yalew,1 Desie Kasew,2 Fikir Asrie1 1Department of Hematology and Immunohematology, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia; 2Department of Medical Microbiology, College of Medicine and Health Science, University of Gondar, Gondar, EthiopiaCorrespondence: Biruk Bayleyegn Email birukbayle@gmail.comBackground: Human immunodeficiency virus (HIV) and intestinal parasites co-infections are the most common causes of clinical illness and death, especially for children living in resource constrained setting. Therefore, the aim of this study was to determine the prevalence and associated factors of intestinal parasites among highly active anti-retroviral therapy (HAART) initiated children.Methods: Cross-sectional study was conducted among 255 HAART initiated HIV-infected children at the University of Gondar Comprehensive Specialized Hospital from January to April 2020. Socio-demographic characteristics were collected using a structured questionnaire via a face-to-face interview. Clinical data of the children were collected by reviewing the medical records. Venous blood was collected for complete blood counts, viral load determination, and blood film examination. Flotation concentration technique was done in addition to direct wet mount for parasitological examination. Bi-variable and multi-variable logistic regression analysis were used to check the presence of significant association, and P-value< 0.05 was considered as statistically significant.Results: The overall prevalence of intestinal parasite infection (IPI) among the study participants was 22.4% (95% CI=17– 28%). The presence of opportunistic infection (AOR=2.09 95% CI=1.81– 5.43), no eating under-cooked animal products (AOR=0.38 95% CI=0.16– 0.94), male sex (AOR=0.45 95% CI=0.22– 0.90), viral load rate > 1,000 copies/mL (AOR=1.80 95% CI=1.67– 4.19), and cytopenia (AOR=2.71 95% CI=1.59– 12.25) showed significant association with the prevalence of IPI.Conclusion: Entamoeba histolytica and Ascaris lumbricoides were the most prevalent intestinal parasites among HAART initiated children. Among HAART initiated children, IPI were associated with gender, cytopenia, viral load, undercooked animal products, and the presence of opportunistic infections. Therefore, health education, prompt treatment, and regular deworming should be implemented to alleviate the burden of intestinal parasites in HIV-infected children.Keywords: intestinal parasite, HIV, children, EthiopiaBayleyegn BWoldu BYalew AKasew DAsrie FDove Medical Pressarticleintestinal parasitehivchildrenethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 81-90 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intestinal parasite hiv children ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	intestinal parasite hiv children ethiopia Immunologic diseases. Allergy RC581-607 Bayleyegn B Woldu B Yalew A Kasew D Asrie F Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
description	Biruk Bayleyegn,1 Berhanu Woldu,1 Aregawi Yalew,1 Desie Kasew,2 Fikir Asrie1 1Department of Hematology and Immunohematology, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia; 2Department of Medical Microbiology, College of Medicine and Health Science, University of Gondar, Gondar, EthiopiaCorrespondence: Biruk Bayleyegn Email birukbayle@gmail.comBackground: Human immunodeficiency virus (HIV) and intestinal parasites co-infections are the most common causes of clinical illness and death, especially for children living in resource constrained setting. Therefore, the aim of this study was to determine the prevalence and associated factors of intestinal parasites among highly active anti-retroviral therapy (HAART) initiated children.Methods: Cross-sectional study was conducted among 255 HAART initiated HIV-infected children at the University of Gondar Comprehensive Specialized Hospital from January to April 2020. Socio-demographic characteristics were collected using a structured questionnaire via a face-to-face interview. Clinical data of the children were collected by reviewing the medical records. Venous blood was collected for complete blood counts, viral load determination, and blood film examination. Flotation concentration technique was done in addition to direct wet mount for parasitological examination. Bi-variable and multi-variable logistic regression analysis were used to check the presence of significant association, and P-value< 0.05 was considered as statistically significant.Results: The overall prevalence of intestinal parasite infection (IPI) among the study participants was 22.4% (95% CI=17– 28%). The presence of opportunistic infection (AOR=2.09 95% CI=1.81– 5.43), no eating under-cooked animal products (AOR=0.38 95% CI=0.16– 0.94), male sex (AOR=0.45 95% CI=0.22– 0.90), viral load rate > 1,000 copies/mL (AOR=1.80 95% CI=1.67– 4.19), and cytopenia (AOR=2.71 95% CI=1.59– 12.25) showed significant association with the prevalence of IPI.Conclusion: Entamoeba histolytica and Ascaris lumbricoides were the most prevalent intestinal parasites among HAART initiated children. Among HAART initiated children, IPI were associated with gender, cytopenia, viral load, undercooked animal products, and the presence of opportunistic infections. Therefore, health education, prompt treatment, and regular deworming should be implemented to alleviate the burden of intestinal parasites in HIV-infected children.Keywords: intestinal parasite, HIV, children, Ethiopia
format	article
author	Bayleyegn B Woldu B Yalew A Kasew D Asrie F
author_facet	Bayleyegn B Woldu B Yalew A Kasew D Asrie F
author_sort	Bayleyegn B
title	Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
title_short	Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
title_full	Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
title_fullStr	Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
title_full_unstemmed	Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
title_sort	prevalence of intestinal parasitic infection and associated factors among haart initiated children attending at university of gondar comprehensive specialized hospital, northwest ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/66bfb7ebc4ac420485a3bd26a3e85e96
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Prevalence of Intestinal Parasitic Infection and Associated Factors Among HAART Initiated Children Attending at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

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