Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents

Abstract Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal pl...

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Autores principales:	Javier Mussin, Viviana Robles-Botero, Rocío Casañas-Pimentel, Florencia Rojas, Letizia Angiolella, Eduardo San Martín-Martínez, Gustavo Giusiano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66c4be5e7b1a46bcaf94e2fb0065d3af
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spelling	oai:doaj.org-article:66c4be5e7b1a46bcaf94e2fb0065d3af2021-12-02T16:14:09ZAntimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents10.1038/s41598-021-94012-y2045-2322https://doaj.org/article/66c4be5e7b1a46bcaf94e2fb0065d3af2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94012-yhttps://doaj.org/toc/2045-2322Abstract Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.Javier MussinViviana Robles-BoteroRocío Casañas-PimentelFlorencia RojasLetizia AngiolellaEduardo San Martín-MartínezGustavo GiusianoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Javier Mussin Viviana Robles-Botero Rocío Casañas-Pimentel Florencia Rojas Letizia Angiolella Eduardo San Martín-Martínez Gustavo Giusiano Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
description	Abstract Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.
format	article
author	Javier Mussin Viviana Robles-Botero Rocío Casañas-Pimentel Florencia Rojas Letizia Angiolella Eduardo San Martín-Martínez Gustavo Giusiano
author_facet	Javier Mussin Viviana Robles-Botero Rocío Casañas-Pimentel Florencia Rojas Letizia Angiolella Eduardo San Martín-Martínez Gustavo Giusiano
author_sort	Javier Mussin
title	Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_short	Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_full	Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_fullStr	Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_full_unstemmed	Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_sort	antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66c4be5e7b1a46bcaf94e2fb0065d3af
work_keys_str_mv	AT javiermussin antimicrobialandcytotoxicactivityofgreensynthesissilvernanoparticlestargetingskinandsofttissueinfectiousagents AT vivianaroblesbotero antimicrobialandcytotoxicactivityofgreensynthesissilvernanoparticlestargetingskinandsofttissueinfectiousagents AT rociocasanaspimentel antimicrobialandcytotoxicactivityofgreensynthesissilvernanoparticlestargetingskinandsofttissueinfectiousagents AT florenciarojas antimicrobialandcytotoxicactivityofgreensynthesissilvernanoparticlestargetingskinandsofttissueinfectiousagents AT letiziaangiolella antimicrobialandcytotoxicactivityofgreensynthesissilvernanoparticlestargetingskinandsofttissueinfectiousagents AT eduardosanmartinmartinez antimicrobialandcytotoxicactivityofgreensynthesissilvernanoparticlestargetingskinandsofttissueinfectiousagents AT gustavogiusiano antimicrobialandcytotoxicactivityofgreensynthesissilvernanoparticlestargetingskinandsofttissueinfectiousagents
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Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents

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