3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance

Abstract The study introduces and validates a novel high-frequency (100–400 Hz bandwidth, 2 kHz sampling frequency) electrocardiographic imaging (HFECGI) technique that measures intramural ventricular electrical activation. Ex-vivo experiments and clinical measurements were employed. Ex-vivo, two pi...

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Autores principales:	Pavel Jurak, Laura R. Bear, Uyên Châu Nguyên, Ivo Viscor, Petr Andrla, Filip Plesinger, Josef Halamek, Vlastimil Vondra, Emma Abell, Matthijs J. M. Cluitmans, Rémi Dubois, Karol Curila, Pavel Leinveber, Frits W. Prinzen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66cc92220c3d4220bd1cf1edbd55e79b
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spelling	oai:doaj.org-article:66cc92220c3d4220bd1cf1edbd55e79b2021-12-02T18:24:54Z3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance10.1038/s41598-021-90963-42045-2322https://doaj.org/article/66cc92220c3d4220bd1cf1edbd55e79b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90963-4https://doaj.org/toc/2045-2322Abstract The study introduces and validates a novel high-frequency (100–400 Hz bandwidth, 2 kHz sampling frequency) electrocardiographic imaging (HFECGI) technique that measures intramural ventricular electrical activation. Ex-vivo experiments and clinical measurements were employed. Ex-vivo, two pig hearts were suspended in a human-torso shaped tank using surface tank electrodes, epicardial electrode sock, and plunge electrodes. We compared conventional epicardial electrocardiographic imaging (ECGI) with intramural activation by HFECGI and verified with sock and plunge electrodes. Clinical importance of HFECGI measurements was performed on 14 patients with variable conduction abnormalities. From 3 × 4 needle and 108 sock electrodes, 256 torso or 184 body surface electrodes records, transmural activation times, sock epicardial activation times, ECGI-derived activation times, and high-frequency activation times were computed. The ex-vivo transmural measurements showed that HFECGI measures intramural electrical activation, and ECGI-HFECGI activation times differences indicate endo-to-epi or epi-to-endo conduction direction. HFECGI-derived volumetric dyssynchrony was significantly lower than epicardial ECGI dyssynchrony. HFECGI dyssynchrony was able to distinguish between intraventricular conduction disturbance and bundle branch block patients.Pavel JurakLaura R. BearUyên Châu NguyênIvo ViscorPetr AndrlaFilip PlesingerJosef HalamekVlastimil VondraEmma AbellMatthijs J. M. CluitmansRémi DuboisKarol CurilaPavel LeinveberFrits W. PrinzenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pavel Jurak Laura R. Bear Uyên Châu Nguyên Ivo Viscor Petr Andrla Filip Plesinger Josef Halamek Vlastimil Vondra Emma Abell Matthijs J. M. Cluitmans Rémi Dubois Karol Curila Pavel Leinveber Frits W. Prinzen 3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance
description	Abstract The study introduces and validates a novel high-frequency (100–400 Hz bandwidth, 2 kHz sampling frequency) electrocardiographic imaging (HFECGI) technique that measures intramural ventricular electrical activation. Ex-vivo experiments and clinical measurements were employed. Ex-vivo, two pig hearts were suspended in a human-torso shaped tank using surface tank electrodes, epicardial electrode sock, and plunge electrodes. We compared conventional epicardial electrocardiographic imaging (ECGI) with intramural activation by HFECGI and verified with sock and plunge electrodes. Clinical importance of HFECGI measurements was performed on 14 patients with variable conduction abnormalities. From 3 × 4 needle and 108 sock electrodes, 256 torso or 184 body surface electrodes records, transmural activation times, sock epicardial activation times, ECGI-derived activation times, and high-frequency activation times were computed. The ex-vivo transmural measurements showed that HFECGI measures intramural electrical activation, and ECGI-HFECGI activation times differences indicate endo-to-epi or epi-to-endo conduction direction. HFECGI-derived volumetric dyssynchrony was significantly lower than epicardial ECGI dyssynchrony. HFECGI dyssynchrony was able to distinguish between intraventricular conduction disturbance and bundle branch block patients.
format	article
author	Pavel Jurak Laura R. Bear Uyên Châu Nguyên Ivo Viscor Petr Andrla Filip Plesinger Josef Halamek Vlastimil Vondra Emma Abell Matthijs J. M. Cluitmans Rémi Dubois Karol Curila Pavel Leinveber Frits W. Prinzen
author_facet	Pavel Jurak Laura R. Bear Uyên Châu Nguyên Ivo Viscor Petr Andrla Filip Plesinger Josef Halamek Vlastimil Vondra Emma Abell Matthijs J. M. Cluitmans Rémi Dubois Karol Curila Pavel Leinveber Frits W. Prinzen
author_sort	Pavel Jurak
title	3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance
title_short	3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance
title_full	3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance
title_fullStr	3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance
title_full_unstemmed	3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance
title_sort	3-dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66cc92220c3d4220bd1cf1edbd55e79b
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3-Dimensional ventricular electrical activation pattern assessed from a novel high-frequency electrocardiographic imaging technique: principles and clinical importance

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