Sex differences in auditory processing vary across estrous cycle

Abstract In humans, females process a sound’s harmonics more robustly than males. As estrogen regulates auditory plasticity in a sex-specific manner in seasonally breeding animals, estrogen signaling is one hypothesized mechanism for this difference in humans. To investigate whether sex differences...

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Autores principales:	Jennifer Krizman, Elena K. Rotondo, Trent Nicol, Nina Kraus, Kasia Bieszczad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66d1c61fe0b74c9b8a9a111f9fe67b9e
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id	oai:doaj.org-article:66d1c61fe0b74c9b8a9a111f9fe67b9e
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spelling	oai:doaj.org-article:66d1c61fe0b74c9b8a9a111f9fe67b9e2021-11-28T12:15:50ZSex differences in auditory processing vary across estrous cycle10.1038/s41598-021-02272-52045-2322https://doaj.org/article/66d1c61fe0b74c9b8a9a111f9fe67b9e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02272-5https://doaj.org/toc/2045-2322Abstract In humans, females process a sound’s harmonics more robustly than males. As estrogen regulates auditory plasticity in a sex-specific manner in seasonally breeding animals, estrogen signaling is one hypothesized mechanism for this difference in humans. To investigate whether sex differences in harmonic encoding vary similarly across the reproductive cycle of mammals, we recorded frequency-following responses (FFRs) to a complex sound in male and female rats. Female FFRs were collected during both low and high levels of circulating estrogen during the estrous cycle. Overall, female rodents had larger harmonic encoding than male rodents, and greater harmonic strength was seen during periods of greater estrogen production in the females. These results argue that hormonal differences, specifically estrogen, underlie sex differences in harmonic encoding in rodents and suggest that a similar mechanism may underlie differences seen in humans.Jennifer KrizmanElena K. RotondoTrent NicolNina KrausKasia BieszczadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer Krizman Elena K. Rotondo Trent Nicol Nina Kraus Kasia Bieszczad Sex differences in auditory processing vary across estrous cycle
description	Abstract In humans, females process a sound’s harmonics more robustly than males. As estrogen regulates auditory plasticity in a sex-specific manner in seasonally breeding animals, estrogen signaling is one hypothesized mechanism for this difference in humans. To investigate whether sex differences in harmonic encoding vary similarly across the reproductive cycle of mammals, we recorded frequency-following responses (FFRs) to a complex sound in male and female rats. Female FFRs were collected during both low and high levels of circulating estrogen during the estrous cycle. Overall, female rodents had larger harmonic encoding than male rodents, and greater harmonic strength was seen during periods of greater estrogen production in the females. These results argue that hormonal differences, specifically estrogen, underlie sex differences in harmonic encoding in rodents and suggest that a similar mechanism may underlie differences seen in humans.
format	article
author	Jennifer Krizman Elena K. Rotondo Trent Nicol Nina Kraus Kasia Bieszczad
author_facet	Jennifer Krizman Elena K. Rotondo Trent Nicol Nina Kraus Kasia Bieszczad
author_sort	Jennifer Krizman
title	Sex differences in auditory processing vary across estrous cycle
title_short	Sex differences in auditory processing vary across estrous cycle
title_full	Sex differences in auditory processing vary across estrous cycle
title_fullStr	Sex differences in auditory processing vary across estrous cycle
title_full_unstemmed	Sex differences in auditory processing vary across estrous cycle
title_sort	sex differences in auditory processing vary across estrous cycle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66d1c61fe0b74c9b8a9a111f9fe67b9e
work_keys_str_mv	AT jenniferkrizman sexdifferencesinauditoryprocessingvaryacrossestrouscycle AT elenakrotondo sexdifferencesinauditoryprocessingvaryacrossestrouscycle AT trentnicol sexdifferencesinauditoryprocessingvaryacrossestrouscycle AT ninakraus sexdifferencesinauditoryprocessingvaryacrossestrouscycle AT kasiabieszczad sexdifferencesinauditoryprocessingvaryacrossestrouscycle
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Sex differences in auditory processing vary across estrous cycle

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