Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy

Abstract Renal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, par...

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Autores principales:	Xia Tan, Guochun Chen, Yu Liu, Letian Zhou, Liyu He, Di Liu, Yexin Liu, Fan Zhang, Huiqiong Li, Hong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66d44f9f5c524ca2b68ddce04148b6ee
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spelling	oai:doaj.org-article:66d44f9f5c524ca2b68ddce04148b6ee2021-12-02T11:41:11ZSerum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy10.1038/s41598-017-05210-62045-2322https://doaj.org/article/66d44f9f5c524ca2b68ddce04148b6ee2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05210-6https://doaj.org/toc/2045-2322Abstract Renal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, particularly in those with severe hypoalbuminemia. This study was designed to investigate the application of serum D-dimer as a predictor for thrombotic events after renal biopsy. 400 consecutive native renal biopsies were prospectively included in this 2-month follow-up study. The overall incidence of bleeding and thrombotic complication is 4%, including hematuria or large perinephric hematoma (2.5%, n = 10) and thrombotic complication (1.5%, n = 6). Compared to low serum D-dimer (<2.00 μg/ml), subjects in the group of high serum D-dimer (≥2.00 μg/ml) were more incline to develop thrombotic complications (9.1% versus 0.3%; RR, 30.33; p < 0.001). D-dimer correlated positively with age (rs = 0.258, P < 0.001). Inverse correlations were found for albumin (rs = −0.339, P < 0.001). Taken together, patients with high serum D-dimer carry an increased risk of thrombotic complications after renal biopsy. Our findings suggest that serum D-dimer can serve as a potential predictor for thrombotic events in patients with kidney disease. Further cautions should be given to these subjects.Xia TanGuochun ChenYu LiuLetian ZhouLiyu HeDi LiuYexin LiuFan ZhangHuiqiong LiHong LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xia Tan Guochun Chen Yu Liu Letian Zhou Liyu He Di Liu Yexin Liu Fan Zhang Huiqiong Li Hong Liu Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
description	Abstract Renal biopsy has been widely recommended in clinic to determine the histological patterns of kidney disease. To prevent bleeding complications, patients should routinely stop anticoagulants prior to renal biopsy. However, patients with kidney disease are susceptible to thromboembolisms, particularly in those with severe hypoalbuminemia. This study was designed to investigate the application of serum D-dimer as a predictor for thrombotic events after renal biopsy. 400 consecutive native renal biopsies were prospectively included in this 2-month follow-up study. The overall incidence of bleeding and thrombotic complication is 4%, including hematuria or large perinephric hematoma (2.5%, n = 10) and thrombotic complication (1.5%, n = 6). Compared to low serum D-dimer (<2.00 μg/ml), subjects in the group of high serum D-dimer (≥2.00 μg/ml) were more incline to develop thrombotic complications (9.1% versus 0.3%; RR, 30.33; p < 0.001). D-dimer correlated positively with age (rs = 0.258, P < 0.001). Inverse correlations were found for albumin (rs = −0.339, P < 0.001). Taken together, patients with high serum D-dimer carry an increased risk of thrombotic complications after renal biopsy. Our findings suggest that serum D-dimer can serve as a potential predictor for thrombotic events in patients with kidney disease. Further cautions should be given to these subjects.
format	article
author	Xia Tan Guochun Chen Yu Liu Letian Zhou Liyu He Di Liu Yexin Liu Fan Zhang Huiqiong Li Hong Liu
author_facet	Xia Tan Guochun Chen Yu Liu Letian Zhou Liyu He Di Liu Yexin Liu Fan Zhang Huiqiong Li Hong Liu
author_sort	Xia Tan
title	Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
title_short	Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
title_full	Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
title_fullStr	Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
title_full_unstemmed	Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
title_sort	serum d-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/66d44f9f5c524ca2b68ddce04148b6ee
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Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy

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