β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta cells.

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Autores principales: Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/66d5119437c34bdaa2ffe7d281b224eb
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spelling oai:doaj.org-article:66d5119437c34bdaa2ffe7d281b224eb2021-12-02T15:38:38Zβ-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions10.1038/ncomms142952041-1723https://doaj.org/article/66d5119437c34bdaa2ffe7d281b224eb2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14295https://doaj.org/toc/2041-1723Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta cells.Lu ZhuJoana AlmaçaPrasanna K. DadiHao HongWataru SakamotoMario RossiRegina J. LeeNicholas C. VierraHuiyan LuYinghong CuiSara M. McMillinNicole A. PerryVsevolod V. GurevichAmy LeeBryan KuoRichard D. LeapmanFranz M. MatschinskyNicolai M. DolibaNikhil M. UrsMarc G. CaronDavid A. JacobsonAlejandro CaicedoJürgen WessNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lu Zhu
Joana Almaça
Prasanna K. Dadi
Hao Hong
Wataru Sakamoto
Mario Rossi
Regina J. Lee
Nicholas C. Vierra
Huiyan Lu
Yinghong Cui
Sara M. McMillin
Nicole A. Perry
Vsevolod V. Gurevich
Amy Lee
Bryan Kuo
Richard D. Leapman
Franz M. Matschinsky
Nicolai M. Doliba
Nikhil M. Urs
Marc G. Caron
David A. Jacobson
Alejandro Caicedo
Jürgen Wess
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
description Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta cells.
format article
author Lu Zhu
Joana Almaça
Prasanna K. Dadi
Hao Hong
Wataru Sakamoto
Mario Rossi
Regina J. Lee
Nicholas C. Vierra
Huiyan Lu
Yinghong Cui
Sara M. McMillin
Nicole A. Perry
Vsevolod V. Gurevich
Amy Lee
Bryan Kuo
Richard D. Leapman
Franz M. Matschinsky
Nicolai M. Doliba
Nikhil M. Urs
Marc G. Caron
David A. Jacobson
Alejandro Caicedo
Jürgen Wess
author_facet Lu Zhu
Joana Almaça
Prasanna K. Dadi
Hao Hong
Wataru Sakamoto
Mario Rossi
Regina J. Lee
Nicholas C. Vierra
Huiyan Lu
Yinghong Cui
Sara M. McMillin
Nicole A. Perry
Vsevolod V. Gurevich
Amy Lee
Bryan Kuo
Richard D. Leapman
Franz M. Matschinsky
Nicolai M. Doliba
Nikhil M. Urs
Marc G. Caron
David A. Jacobson
Alejandro Caicedo
Jürgen Wess
author_sort Lu Zhu
title β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
title_short β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
title_full β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
title_fullStr β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
title_full_unstemmed β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
title_sort β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/66d5119437c34bdaa2ffe7d281b224eb
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