Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy

Abstract The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classifi...

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Autores principales:	Yoei Miyabe, Kazunori Karasawa, Kenichi Akiyama, Shota Ogura, Tomo Takabe, Naoko Sugiura, Momoko Seki, Yuko Iwabuchi, Norio Hanafusa, Keiko Uchida, Kosaku Nitta, Takahito Moriyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66d9308949a64520b8a80b8d78f765f7
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spelling	oai:doaj.org-article:66d9308949a64520b8a80b8d78f765f72021-12-02T13:30:09ZGrading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy10.1038/s41598-021-82967-x2045-2322https://doaj.org/article/66d9308949a64520b8a80b8d78f765f72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82967-xhttps://doaj.org/toc/2045-2322Abstract The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification system (O-grade) that utilised the total MEST-C score (O-grade I: 0–1, II: 2–4, and III: 5–7 points), and the 10-year renal prognosis was analysed. The clinical findings became significantly severer with increasing O-grades, and the renal survival rate by the Kaplan–Meier method was 94.1%, 86.9%, and 74.1% for O-grades I, II, and III, respectively. The hazard ratios (HRs) for O-grades II and III with reference to O-grade I were 2.8 (95% confidence interval [CI] 1.3–6.0) and 6.3 (95% CI 2.7–14.5), respectively. In the multivariate analysis, mean arterial pressure and eGFR, proteinuria at the time of biopsy, treatment of corticosteroids/immunosuppressors, and O-grade (HR 1.63; 95% CI 1.11–2.38) were the independent factors predicting renal prognosis. Among the nine groups classified using the O-grade and Japanese clinical-grade, the renal prognosis had an HR of 15.2 (95% CI 3.5–67) in the severest group. The O-grade classified by the total score of the Oxford classification was associated with renal prognosis.Yoei MiyabeKazunori KarasawaKenichi AkiyamaShota OguraTomo TakabeNaoko SugiuraMomoko SekiYuko IwabuchiNorio HanafusaKeiko UchidaKosaku NittaTakahito MoriyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoei Miyabe Kazunori Karasawa Kenichi Akiyama Shota Ogura Tomo Takabe Naoko Sugiura Momoko Seki Yuko Iwabuchi Norio Hanafusa Keiko Uchida Kosaku Nitta Takahito Moriyama Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy
description	Abstract The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification system (O-grade) that utilised the total MEST-C score (O-grade I: 0–1, II: 2–4, and III: 5–7 points), and the 10-year renal prognosis was analysed. The clinical findings became significantly severer with increasing O-grades, and the renal survival rate by the Kaplan–Meier method was 94.1%, 86.9%, and 74.1% for O-grades I, II, and III, respectively. The hazard ratios (HRs) for O-grades II and III with reference to O-grade I were 2.8 (95% confidence interval [CI] 1.3–6.0) and 6.3 (95% CI 2.7–14.5), respectively. In the multivariate analysis, mean arterial pressure and eGFR, proteinuria at the time of biopsy, treatment of corticosteroids/immunosuppressors, and O-grade (HR 1.63; 95% CI 1.11–2.38) were the independent factors predicting renal prognosis. Among the nine groups classified using the O-grade and Japanese clinical-grade, the renal prognosis had an HR of 15.2 (95% CI 3.5–67) in the severest group. The O-grade classified by the total score of the Oxford classification was associated with renal prognosis.
format	article
author	Yoei Miyabe Kazunori Karasawa Kenichi Akiyama Shota Ogura Tomo Takabe Naoko Sugiura Momoko Seki Yuko Iwabuchi Norio Hanafusa Keiko Uchida Kosaku Nitta Takahito Moriyama
author_facet	Yoei Miyabe Kazunori Karasawa Kenichi Akiyama Shota Ogura Tomo Takabe Naoko Sugiura Momoko Seki Yuko Iwabuchi Norio Hanafusa Keiko Uchida Kosaku Nitta Takahito Moriyama
author_sort	Yoei Miyabe
title	Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy
title_short	Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy
title_full	Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy
title_fullStr	Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy
title_full_unstemmed	Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy
title_sort	grading system utilising the total score of oxford classification for predicting renal prognosis in iga nephropathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66d9308949a64520b8a80b8d78f765f7
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Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy

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