Diagnostic challenges in primary orbital fibrosarcoma: a case report

Brittni A Scruggs, Son T Ho, Alejandra A Valenzuela Department of Ophthalmology, School of Medicine, Tulane University, New Orleans, LA, USA Abstract: Fibrosarcoma is a rare and malignant spindle cell tumor of mesenchymal origin that infrequently presents in the orbit. Evolving d...

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Autores principales:	Scruggs BA, Ho ST, Valenzuela AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/66e4696a41c24bf0a4e5710efb23e914
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spelling	oai:doaj.org-article:66e4696a41c24bf0a4e5710efb23e9142021-12-02T05:28:01ZDiagnostic challenges in primary orbital fibrosarcoma: a case report1177-5483https://doaj.org/article/66e4696a41c24bf0a4e5710efb23e9142014-11-01T00:00:00Zhttp://www.dovepress.com/diagnostic-challenges-in-primary-orbital-fibrosarcoma-a-case-report-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Brittni A Scruggs, Son T Ho, Alejandra A Valenzuela Department of Ophthalmology, School of Medicine, Tulane University, New Orleans, LA, USA Abstract: Fibrosarcoma is a rare and malignant spindle cell tumor of mesenchymal origin that infrequently presents in the orbit. Evolving diagnostic criteria confound the identification of these tumors, as well as the interpretation of previous studies on this unusual entity. We report a case of a 66-year-old man with a mass on his left inferior orbit, with associated paresthesia. A computed tomography (CT) scan showed a lesion on the left anteroinferomedial orbit, with bone erosion. An en bloc surgical excision followed by a thorough immunohistologic evaluation allowed diagnosis of an orbital fibrosarcoma. The patient has had no recurrence after 14 months of follow up. Once a commonly identified soft tissue malignancy, fibrosarcoma has become a diagnosis of exclusion as a result of improved diagnostic and classification techniques, such as immunohistochemistry and fluorescence in situ hybridization (FISH). This type of soft tissue tumor is now an uncommon entity, and we report the first case of a primary orbital fibrosarcoma in an adult, using modern diagnostic and classification methods. Keywords: spindle cell orbital tumor, mesenchymal tumor, soft tissue malignancy, fibroblastsScruggs BAHo STValenzuela AADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2319-2323 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Scruggs BA Ho ST Valenzuela AA Diagnostic challenges in primary orbital fibrosarcoma: a case report
description	Brittni A Scruggs, Son T Ho, Alejandra A Valenzuela Department of Ophthalmology, School of Medicine, Tulane University, New Orleans, LA, USA Abstract: Fibrosarcoma is a rare and malignant spindle cell tumor of mesenchymal origin that infrequently presents in the orbit. Evolving diagnostic criteria confound the identification of these tumors, as well as the interpretation of previous studies on this unusual entity. We report a case of a 66-year-old man with a mass on his left inferior orbit, with associated paresthesia. A computed tomography (CT) scan showed a lesion on the left anteroinferomedial orbit, with bone erosion. An en bloc surgical excision followed by a thorough immunohistologic evaluation allowed diagnosis of an orbital fibrosarcoma. The patient has had no recurrence after 14 months of follow up. Once a commonly identified soft tissue malignancy, fibrosarcoma has become a diagnosis of exclusion as a result of improved diagnostic and classification techniques, such as immunohistochemistry and fluorescence in situ hybridization (FISH). This type of soft tissue tumor is now an uncommon entity, and we report the first case of a primary orbital fibrosarcoma in an adult, using modern diagnostic and classification methods. Keywords: spindle cell orbital tumor, mesenchymal tumor, soft tissue malignancy, fibroblasts
format	article
author	Scruggs BA Ho ST Valenzuela AA
author_facet	Scruggs BA Ho ST Valenzuela AA
author_sort	Scruggs BA
title	Diagnostic challenges in primary orbital fibrosarcoma: a case report
title_short	Diagnostic challenges in primary orbital fibrosarcoma: a case report
title_full	Diagnostic challenges in primary orbital fibrosarcoma: a case report
title_fullStr	Diagnostic challenges in primary orbital fibrosarcoma: a case report
title_full_unstemmed	Diagnostic challenges in primary orbital fibrosarcoma: a case report
title_sort	diagnostic challenges in primary orbital fibrosarcoma: a case report
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/66e4696a41c24bf0a4e5710efb23e914
work_keys_str_mv	AT scruggsba diagnosticchallengesinprimaryorbitalfibrosarcomaacasereport AT host diagnosticchallengesinprimaryorbitalfibrosarcomaacasereport AT valenzuelaaa diagnosticchallengesinprimaryorbitalfibrosarcomaacasereport
_version_	1718400415805997056

Diagnostic challenges in primary orbital fibrosarcoma: a case report

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