Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine

The antibiotic D-cycloserine (DCS) targets the peptidoglycan biosynthesis enzyme D-Ala-D-Ala ligase (Ddl). Here the authors reveal the DCS inhibitory mechanism by determining the structure of E. coli DdlB with a phosphorylated DCS molecule in the active site that formed in crystallo and mimics the D...

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Autores principales:	Sarah Batson, Cesira de Chiara, Vita Majce, Adrian J. Lloyd, Stanislav Gobec, Dean Rea, Vilmos Fülöp, Christopher W. Thoroughgood, Katie J. Simmons, Christopher G. Dowson, Colin W. G. Fishwick, Luiz Pedro S. de Carvalho, David I. Roper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66e59bce52674d29b83d6b33b62cc099
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spelling	oai:doaj.org-article:66e59bce52674d29b83d6b33b62cc0992021-12-02T14:40:33ZInhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine10.1038/s41467-017-02118-72041-1723https://doaj.org/article/66e59bce52674d29b83d6b33b62cc0992017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02118-7https://doaj.org/toc/2041-1723The antibiotic D-cycloserine (DCS) targets the peptidoglycan biosynthesis enzyme D-Ala-D-Ala ligase (Ddl). Here the authors reveal the DCS inhibitory mechanism by determining the structure of E. coli DdlB with a phosphorylated DCS molecule in the active site that formed in crystallo and mimics the D-alanyl phosphate intermediate.Sarah BatsonCesira de ChiaraVita MajceAdrian J. LloydStanislav GobecDean ReaVilmos FülöpChristopher W. ThoroughgoodKatie J. SimmonsChristopher G. DowsonColin W. G. FishwickLuiz Pedro S. de CarvalhoDavid I. RoperNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Batson Cesira de Chiara Vita Majce Adrian J. Lloyd Stanislav Gobec Dean Rea Vilmos Fülöp Christopher W. Thoroughgood Katie J. Simmons Christopher G. Dowson Colin W. G. Fishwick Luiz Pedro S. de Carvalho David I. Roper Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
description	The antibiotic D-cycloserine (DCS) targets the peptidoglycan biosynthesis enzyme D-Ala-D-Ala ligase (Ddl). Here the authors reveal the DCS inhibitory mechanism by determining the structure of E. coli DdlB with a phosphorylated DCS molecule in the active site that formed in crystallo and mimics the D-alanyl phosphate intermediate.
format	article
author	Sarah Batson Cesira de Chiara Vita Majce Adrian J. Lloyd Stanislav Gobec Dean Rea Vilmos Fülöp Christopher W. Thoroughgood Katie J. Simmons Christopher G. Dowson Colin W. G. Fishwick Luiz Pedro S. de Carvalho David I. Roper
author_facet	Sarah Batson Cesira de Chiara Vita Majce Adrian J. Lloyd Stanislav Gobec Dean Rea Vilmos Fülöp Christopher W. Thoroughgood Katie J. Simmons Christopher G. Dowson Colin W. G. Fishwick Luiz Pedro S. de Carvalho David I. Roper
author_sort	Sarah Batson
title	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
title_short	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
title_full	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
title_fullStr	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
title_full_unstemmed	Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
title_sort	inhibition of d-ala:d-ala ligase through a phosphorylated form of the antibiotic d-cycloserine
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/66e59bce52674d29b83d6b33b62cc099
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Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine

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