Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
The antibiotic D-cycloserine (DCS) targets the peptidoglycan biosynthesis enzyme D-Ala-D-Ala ligase (Ddl). Here the authors reveal the DCS inhibitory mechanism by determining the structure of E. coli DdlB with a phosphorylated DCS molecule in the active site that formed in crystallo and mimics the D...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/66e59bce52674d29b83d6b33b62cc099 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|