Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus

Abstract Human beta defensins (hBDs) may play an important role in the progression of lichen sclerosus (LS), due to their ability to induce excessive stimulation of extracellular matrix synthesis and fibroblast activation. The genetic ability of the individual to produce defensins, the presence of m...

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Autores principales:	Alexandra Brunner, Márta Medvecz, Nóra Makra, Miklós Sárdy, Kinga Komka, Máté Gugolya, Dóra Szabó, Márió Gajdács, Eszter Ostorházi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/66e68bd00524467aaa5c69062564601e
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spelling	oai:doaj.org-article:66e68bd00524467aaa5c69062564601e2021-12-02T18:49:30ZHuman beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus10.1038/s41598-021-94880-42045-2322https://doaj.org/article/66e68bd00524467aaa5c69062564601e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94880-4https://doaj.org/toc/2045-2322Abstract Human beta defensins (hBDs) may play an important role in the progression of lichen sclerosus (LS), due to their ability to induce excessive stimulation of extracellular matrix synthesis and fibroblast activation. The genetic ability of the individual to produce defensins, the presence of microbes influencing defensin production, and the sensitivity of microbes to defensins together regulate the formation of an ever-changing balance between defensin levels and microbiome composition. We investigated the potential differences in postmenopausal vaginal microbiome composition and vaginal hBD levels in LS patients compared to non-LS controls. LS patients exhibited significantly lower levels of hBD1 (p = 0.0003), and significantly higher levels of hBD2 (p = 0.0359) and hBD3 (p = 0.0002), compared to the control group. The microbiome of the LS patients was dominated by possibly harmful bacteria including Lactobacillus iners, Streptococcus anginosus or Gardnerella vaginalis known to initiate direct or indirect damage by increasing defensin level production. Our observations highlight that correcting the composition of the microbiome may be applicable in supplementary LS therapy by targeting the restoration of the beneficial flora that does not increase hBD2-3 production.Alexandra BrunnerMárta MedveczNóra MakraMiklós SárdyKinga KomkaMáté GugolyaDóra SzabóMárió GajdácsEszter OstorháziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandra Brunner Márta Medvecz Nóra Makra Miklós Sárdy Kinga Komka Máté Gugolya Dóra Szabó Márió Gajdács Eszter Ostorházi Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus
description	Abstract Human beta defensins (hBDs) may play an important role in the progression of lichen sclerosus (LS), due to their ability to induce excessive stimulation of extracellular matrix synthesis and fibroblast activation. The genetic ability of the individual to produce defensins, the presence of microbes influencing defensin production, and the sensitivity of microbes to defensins together regulate the formation of an ever-changing balance between defensin levels and microbiome composition. We investigated the potential differences in postmenopausal vaginal microbiome composition and vaginal hBD levels in LS patients compared to non-LS controls. LS patients exhibited significantly lower levels of hBD1 (p = 0.0003), and significantly higher levels of hBD2 (p = 0.0359) and hBD3 (p = 0.0002), compared to the control group. The microbiome of the LS patients was dominated by possibly harmful bacteria including Lactobacillus iners, Streptococcus anginosus or Gardnerella vaginalis known to initiate direct or indirect damage by increasing defensin level production. Our observations highlight that correcting the composition of the microbiome may be applicable in supplementary LS therapy by targeting the restoration of the beneficial flora that does not increase hBD2-3 production.
format	article
author	Alexandra Brunner Márta Medvecz Nóra Makra Miklós Sárdy Kinga Komka Máté Gugolya Dóra Szabó Márió Gajdács Eszter Ostorházi
author_facet	Alexandra Brunner Márta Medvecz Nóra Makra Miklós Sárdy Kinga Komka Máté Gugolya Dóra Szabó Márió Gajdács Eszter Ostorházi
author_sort	Alexandra Brunner
title	Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus
title_short	Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus
title_full	Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus
title_fullStr	Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus
title_full_unstemmed	Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus
title_sort	human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66e68bd00524467aaa5c69062564601e
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Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus

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