Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing

Replenishing key extracellular matrix (ECM) proteins facilitate wound healing through unclear mechanisms. Here the authors report that injury-triggered Agrin, an ECM proteoglycan, tunes a mechanocompetent niche by engaging MMP-12, thereby enforcing efficient skin wound healing.

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Autores principales:	Sayan Chakraborty, Divyaleka Sampath, Melissa Ong Yu Lin, Matthew Bilton, Cheng-Kuang Huang, Mui Hoon Nai, Kizito Njah, Pierre-Alexis Goy, Cheng-Chun Wang, Ernesto Guccione, Chwee-Teck Lim, Wanjin Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66e7f31bc2564edc8b704e9a42602d0d
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spelling	oai:doaj.org-article:66e7f31bc2564edc8b704e9a42602d0d2021-11-08T11:08:39ZAgrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing10.1038/s41467-021-26717-72041-1723https://doaj.org/article/66e7f31bc2564edc8b704e9a42602d0d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26717-7https://doaj.org/toc/2041-1723Replenishing key extracellular matrix (ECM) proteins facilitate wound healing through unclear mechanisms. Here the authors report that injury-triggered Agrin, an ECM proteoglycan, tunes a mechanocompetent niche by engaging MMP-12, thereby enforcing efficient skin wound healing.Sayan ChakrabortyDivyaleka SampathMelissa Ong Yu LinMatthew BiltonCheng-Kuang HuangMui Hoon NaiKizito NjahPierre-Alexis GoyCheng-Chun WangErnesto GuccioneChwee-Teck LimWanjin HongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sayan Chakraborty Divyaleka Sampath Melissa Ong Yu Lin Matthew Bilton Cheng-Kuang Huang Mui Hoon Nai Kizito Njah Pierre-Alexis Goy Cheng-Chun Wang Ernesto Guccione Chwee-Teck Lim Wanjin Hong Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
description	Replenishing key extracellular matrix (ECM) proteins facilitate wound healing through unclear mechanisms. Here the authors report that injury-triggered Agrin, an ECM proteoglycan, tunes a mechanocompetent niche by engaging MMP-12, thereby enforcing efficient skin wound healing.
format	article
author	Sayan Chakraborty Divyaleka Sampath Melissa Ong Yu Lin Matthew Bilton Cheng-Kuang Huang Mui Hoon Nai Kizito Njah Pierre-Alexis Goy Cheng-Chun Wang Ernesto Guccione Chwee-Teck Lim Wanjin Hong
author_facet	Sayan Chakraborty Divyaleka Sampath Melissa Ong Yu Lin Matthew Bilton Cheng-Kuang Huang Mui Hoon Nai Kizito Njah Pierre-Alexis Goy Cheng-Chun Wang Ernesto Guccione Chwee-Teck Lim Wanjin Hong
author_sort	Sayan Chakraborty
title	Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
title_short	Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
title_full	Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
title_fullStr	Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
title_full_unstemmed	Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
title_sort	agrin-matrix metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66e7f31bc2564edc8b704e9a42602d0d
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Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing

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