Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and Activating motif interact and modulate G proteins...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alain Ibáñez de Opakua, Kshitij Parag-Sharma, Vincent DiGiacomo, Nekane Merino, Anthony Leyme, Arthur Marivin, Maider Villate, Lien T. Nguyen, Miguel Angel de la Cruz-Morcillo, Juan B. Blanco-Canosa, Sekar Ramachandran, George S. Baillie, Richard A. Cerione, Francisco J. Blanco, Mikel Garcia-Marcos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/66ed9d678b9b4909beb7dc11e3606d2b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:66ed9d678b9b4909beb7dc11e3606d2b
record_format	dspace
spelling	oai:doaj.org-article:66ed9d678b9b4909beb7dc11e3606d2b2021-12-02T14:42:23ZMolecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif10.1038/ncomms151632041-1723https://doaj.org/article/66ed9d678b9b4909beb7dc11e3606d2b2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15163https://doaj.org/toc/2041-1723Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and Activating motif interact and modulate G proteins.Alain Ibáñez de OpakuaKshitij Parag-SharmaVincent DiGiacomoNekane MerinoAnthony LeymeArthur MarivinMaider VillateLien T. NguyenMiguel Angel de la Cruz-MorcilloJuan B. Blanco-CanosaSekar RamachandranGeorge S. BaillieRichard A. CerioneFrancisco J. BlancoMikel Garcia-MarcosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alain Ibáñez de Opakua Kshitij Parag-Sharma Vincent DiGiacomo Nekane Merino Anthony Leyme Arthur Marivin Maider Villate Lien T. Nguyen Miguel Angel de la Cruz-Morcillo Juan B. Blanco-Canosa Sekar Ramachandran George S. Baillie Richard A. Cerione Francisco J. Blanco Mikel Garcia-Marcos Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
description	Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and Activating motif interact and modulate G proteins.
format	article
author	Alain Ibáñez de Opakua Kshitij Parag-Sharma Vincent DiGiacomo Nekane Merino Anthony Leyme Arthur Marivin Maider Villate Lien T. Nguyen Miguel Angel de la Cruz-Morcillo Juan B. Blanco-Canosa Sekar Ramachandran George S. Baillie Richard A. Cerione Francisco J. Blanco Mikel Garcia-Marcos
author_facet	Alain Ibáñez de Opakua Kshitij Parag-Sharma Vincent DiGiacomo Nekane Merino Anthony Leyme Arthur Marivin Maider Villate Lien T. Nguyen Miguel Angel de la Cruz-Morcillo Juan B. Blanco-Canosa Sekar Ramachandran George S. Baillie Richard A. Cerione Francisco J. Blanco Mikel Garcia-Marcos
author_sort	Alain Ibáñez de Opakua
title	Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
title_short	Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
title_full	Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
title_fullStr	Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
title_full_unstemmed	Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
title_sort	molecular mechanism of gαi activation by non-gpcr proteins with a gα-binding and activating motif
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/66ed9d678b9b4909beb7dc11e3606d2b
work_keys_str_mv	AT alainibanezdeopakua molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT kshitijparagsharma molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT vincentdigiacomo molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT nekanemerino molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT anthonyleyme molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT arthurmarivin molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT maidervillate molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT lientnguyen molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT miguelangeldelacruzmorcillo molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT juanbblancocanosa molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT sekarramachandran molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT georgesbaillie molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT richardacerione molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT franciscojblanco molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif AT mikelgarciamarcos molecularmechanismofgaiactivationbynongpcrproteinswithagabindingandactivatingmotif
_version_	1718389692627419136

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

Ejemplares similares