Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

QR Code

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and Activating motif interact and modulate G proteins...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Alain Ibáñez de Opakua, Kshitij Parag-Sharma, Vincent DiGiacomo, Nekane Merino, Anthony Leyme, Arthur Marivin, Maider Villate, Lien T. Nguyen, Miguel Angel de la Cruz-Morcillo, Juan B. Blanco-Canosa, Sekar Ramachandran, George S. Baillie, Richard A. Cerione, Francisco J. Blanco, Mikel Garcia-Marcos
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/66ed9d678b9b4909beb7dc11e3606d2b
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

The Gαi-GIV binding interface is a druggable protein-protein interaction
par: Vincent DiGiacomo, et autres
Publié: (2017)

Heterotrimeric G Proteins in Plants: Canonical and Atypical Gα Subunits
par: Natsumi Maruta, et autres
Publié: (2021)

Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling.
par: Ralf C Kling, et autres
Publié: (2013)

Coevolution underlies GPCR-G protein selectivity and functionality
par: Min Jae Seo, et autres
Publié: (2021)

Gαq activation modulates autophagy by promoting mTORC1 signaling
par: Sofía Cabezudo, et autres
Publié: (2021)

A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.
par: Dustin E Bosch, et autres
Publié: (2012)

Development of an antibody fragment that stabilizes GPCR/G-protein complexes
par: Shoji Maeda, et autres
Publié: (2018)

Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation
par: Misun Kwak, et autres
Publié: (2018)

Gα15 in early onset of pancreatic ductal adenocarcinoma
par: Giulio Innamorati, et autres
Publié: (2021)

Deterioration of the Gαo vomeronasal pathway in sexually dimorphic mammals.
par: Rodrigo Suárez, et autres
Publié: (2011)

Targeting Gα13-integrin interaction ameliorates systemic inflammation
par: Ni Cheng, et autres
Publié: (2021)

The tumor necrosis factor α (-308 A/G) polymorphism is associated with cystic fibrosis in Mexican patients.
par: Celia N Sanchez-Dominguez, et autres
Publié: (2014)

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
par: Jenna Scotcher, et autres
Publié: (2016)

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
par: Levi J. McClelland, et autres
Publié: (2020)

A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
par: Yaqi Deng, et autres
Publié: (2017)

Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.
par: Ralf C Kling, et autres
Publié: (2014)

ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells
par: Rabia U. Malik, et autres
Publié: (2017)

Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
par: Eunyoung Jeong, et autres
Publié: (2021)

Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.
par: Niklas K U Koehler, et autres
Publié: (2013)

Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation
par: Erik H. Klontz, et autres
Publié: (2020)

Sensory Afferent Renal Nerve Activated Gαi2 Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges
par: Jesse D. Moreira, et autres
Publié: (2021)

A Sugarcane G-Protein-Coupled Receptor, ShGPCR1, Confers Tolerance to Multiple Abiotic Stresses
par: Manikandan Ramasamy, et autres
Publié: (2021)

Gα₁₂ drives invasion of oral squamous cell carcinoma through up-regulation of proinflammatory cytokines.
par: Shiou-Ling Jian, et autres
Publié: (2013)

Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
par: Rachel McMullan, et autres
Publié: (2012)

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
par: Selena S. Schattauer, et autres
Publié: (2017)

EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
par: Katie S. Kindt, et autres
Publié: (2021)

Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling
par: Tejas M. Gupte, et autres
Publié: (2019)

Facile Synthesis of Mesoporous α-Fe2O3@g-C3N4-NCs for Efficient Bifunctional Electro-catalytic Activity (OER/ORR)
par: Osamah Alduhaish, et autres
Publié: (2019)

Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
par: Jialu Wang, et autres
Publié: (2017)

An ATX-LPA6-Gα13-ROCK axis shapes and maintains caudal vein plexus in zebrafish
par: Ryohei Okasato, et autres
Publié: (2021)

Identification of subunit-subunit interaction sites in αA-WT crystallin and mutant αA-G98R crystallin using isotope-labeled cross-linker and mass spectrometry.
par: Rama Kannan, et autres
Publié: (2013)

Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling
par: David M. Favara, et autres
Publié: (2021)

Analyses of Gnai3-iresGFP reporter mice reveal unknown Gαi3 expression sites
par: Veronika Leiss, et autres
Publié: (2021)

Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α (AMPKα)
par: Min Zhang, et autres
Publié: (2021)

Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.
par: Chih-Chien Wang, et autres
Publié: (2021)

Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents
par: Eun-Seon Yoo, et autres
Publié: (2021)

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
par: Dhiraj Srivastava, et autres
Publié: (2019)

Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
par: Mengrui Wu, et autres
Publié: (2017)

Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis
par: Chih-Chien Wang, et autres
Publié: (2021)

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
par: Li Xue, et autres
Publié: (2019)