Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women

BackgroundPreeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for GH has not been established. We aimed to determine the association between GH a...

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Autores principales:	Hilde Kristin Refvik Riise, Gerhard Sulo, Grethe S. Tell, Jannicke Igland, Ottar Nygård, Ann‐Charlotte Iversen, Anne Kjersti Daltveit
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	cardiovascular disease fetal growth restriction gestational hypertension preeclampsia/pregnancy preterm delivery Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/66edc275d455415c8d851a791ed22874
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spelling	oai:doaj.org-article:66edc275d455415c8d851a791ed228742021-11-12T17:01:57ZAssociation Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women10.1161/JAHA.117.0083372047-9980https://doaj.org/article/66edc275d455415c8d851a791ed228742018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.117.008337https://doaj.org/toc/2047-9980BackgroundPreeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for GH has not been established. We aimed to determine the association between GH and subsequent CVD, and explore the additional role of small‐for‐gestational‐age infants, preterm delivery, and parity. Methods and ResultsData from the Medical Birth Registry of Norway were linked to the Cardiovascular Disease in Norway project and the Norwegian Cause of Death Registry. Hazard ratios and 95% confidence intervals were computed using Cox proportional hazard regression, comparing women with and without GH during their first and/or second pregnancy. We included all women with a first delivery from 1980 through 2009 (n=617 589) and followed them for a median of 14.3 (quartile 1–quartile 3: 6.9–21.5) years. Women with GH in the first pregnancy had 1.8‐fold (95% confidence interval, 1.7–2.0) higher risk of subsequent CVD compared with women without any hypertensive pregnancy disorder. When GH occurred in combination with small‐for‐gestational‐age infants and/or preterm delivery, the hazard ratio was 2.6 (95% confidence interval, 2.3–3.0). When women with GH were compared with women with preeclampsia, the risk of CVD was comparable when the pregnancy complications occurred in either the first or second pregnancy but was significantly higher for preeclampsia without complications when the disorder occurred in both pregnancies. ConclusionsGH was associated with increased risk of subsequent CVD, and the highest risk was observed when GH was combined with small‐for‐gestational‐age infants and/or preterm delivery.Hilde Kristin Refvik RiiseGerhard SuloGrethe S. TellJannicke IglandOttar NygårdAnn‐Charlotte IversenAnne Kjersti DaltveitWileyarticlecardiovascular diseasefetal growth restrictiongestational hypertensionpreeclampsia/pregnancypreterm deliveryDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease fetal growth restriction gestational hypertension preeclampsia/pregnancy preterm delivery Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cardiovascular disease fetal growth restriction gestational hypertension preeclampsia/pregnancy preterm delivery Diseases of the circulatory (Cardiovascular) system RC666-701 Hilde Kristin Refvik Riise Gerhard Sulo Grethe S. Tell Jannicke Igland Ottar Nygård Ann‐Charlotte Iversen Anne Kjersti Daltveit Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women
description	BackgroundPreeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for GH has not been established. We aimed to determine the association between GH and subsequent CVD, and explore the additional role of small‐for‐gestational‐age infants, preterm delivery, and parity. Methods and ResultsData from the Medical Birth Registry of Norway were linked to the Cardiovascular Disease in Norway project and the Norwegian Cause of Death Registry. Hazard ratios and 95% confidence intervals were computed using Cox proportional hazard regression, comparing women with and without GH during their first and/or second pregnancy. We included all women with a first delivery from 1980 through 2009 (n=617 589) and followed them for a median of 14.3 (quartile 1–quartile 3: 6.9–21.5) years. Women with GH in the first pregnancy had 1.8‐fold (95% confidence interval, 1.7–2.0) higher risk of subsequent CVD compared with women without any hypertensive pregnancy disorder. When GH occurred in combination with small‐for‐gestational‐age infants and/or preterm delivery, the hazard ratio was 2.6 (95% confidence interval, 2.3–3.0). When women with GH were compared with women with preeclampsia, the risk of CVD was comparable when the pregnancy complications occurred in either the first or second pregnancy but was significantly higher for preeclampsia without complications when the disorder occurred in both pregnancies. ConclusionsGH was associated with increased risk of subsequent CVD, and the highest risk was observed when GH was combined with small‐for‐gestational‐age infants and/or preterm delivery.
format	article
author	Hilde Kristin Refvik Riise Gerhard Sulo Grethe S. Tell Jannicke Igland Ottar Nygård Ann‐Charlotte Iversen Anne Kjersti Daltveit
author_facet	Hilde Kristin Refvik Riise Gerhard Sulo Grethe S. Tell Jannicke Igland Ottar Nygård Ann‐Charlotte Iversen Anne Kjersti Daltveit
author_sort	Hilde Kristin Refvik Riise
title	Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women
title_short	Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women
title_full	Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women
title_fullStr	Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women
title_full_unstemmed	Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women
title_sort	association between gestational hypertension and risk of cardiovascular disease among 617 589 norwegian women
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/66edc275d455415c8d851a791ed22874
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Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women

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