Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism

Rigby et al. use transgenic mice that are deficient in the endoplasmic reticulum acetyltransferases Atase1 or Atase2 to demonstrate the differential role of these enzymes in the regulation of reticulophagy and macroautophagy. Their study emphasizes ATase1 as a potential translational target for dise...

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Autores principales:	Michael J. Rigby, Alexis J. Lawton, Gulpreet Kaur, Varuna C. Banduseela, William E. Kamm, Aparna Lakkaraju, John M. Denu, Luigi Puglielli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/66edeebf23cd4de3a63d2711efd2742c
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spelling	oai:doaj.org-article:66edeebf23cd4de3a63d2711efd2742c2021-12-02T15:51:05ZEndoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism10.1038/s42003-021-01992-82399-3642https://doaj.org/article/66edeebf23cd4de3a63d2711efd2742c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01992-8https://doaj.org/toc/2399-3642Rigby et al. use transgenic mice that are deficient in the endoplasmic reticulum acetyltransferases Atase1 or Atase2 to demonstrate the differential role of these enzymes in the regulation of reticulophagy and macroautophagy. Their study emphasizes ATase1 as a potential translational target for diseases characterized by toxic protein aggregation in the secretory pathway.Michael J. RigbyAlexis J. LawtonGulpreet KaurVaruna C. BanduseelaWilliam E. KammAparna LakkarajuJohn M. DenuLuigi PuglielliNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michael J. Rigby Alexis J. Lawton Gulpreet Kaur Varuna C. Banduseela William E. Kamm Aparna Lakkaraju John M. Denu Luigi Puglielli Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism
description	Rigby et al. use transgenic mice that are deficient in the endoplasmic reticulum acetyltransferases Atase1 or Atase2 to demonstrate the differential role of these enzymes in the regulation of reticulophagy and macroautophagy. Their study emphasizes ATase1 as a potential translational target for diseases characterized by toxic protein aggregation in the secretory pathway.
format	article
author	Michael J. Rigby Alexis J. Lawton Gulpreet Kaur Varuna C. Banduseela William E. Kamm Aparna Lakkaraju John M. Denu Luigi Puglielli
author_facet	Michael J. Rigby Alexis J. Lawton Gulpreet Kaur Varuna C. Banduseela William E. Kamm Aparna Lakkaraju John M. Denu Luigi Puglielli
author_sort	Michael J. Rigby
title	Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism
title_short	Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism
title_full	Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism
title_fullStr	Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism
title_full_unstemmed	Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism
title_sort	endoplasmic reticulum acetyltransferases atase1 and atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-coa metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/66edeebf23cd4de3a63d2711efd2742c
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Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism

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