Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and...
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Nature Portfolio
2019
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oai:doaj.org-article:66f4ba80a7fd4950b7b10906aec986dc2021-12-02T16:58:28ZPhysical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis10.1038/s41467-019-09667-z2041-1723https://doaj.org/article/66f4ba80a7fd4950b7b10906aec986dc2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09667-zhttps://doaj.org/toc/2041-1723Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and redundant roles in fine-tuning gut barrier homeostasis.Karolina SlowickaInmaculada Serramito-GómezEmilio Boada-RomeroArne MartensMozes SzeIoanna PettaHanna K. VikkulaRiet De RyckeEef ParthoensSaskia LippensSavvas N. SavvidesAndy WullaertLars VereeckeFelipe X. Pimentel-MuiñosGeert van LooNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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| topic |
Science Q |
| spellingShingle |
Science Q Karolina Slowicka Inmaculada Serramito-Gómez Emilio Boada-Romero Arne Martens Mozes Sze Ioanna Petta Hanna K. Vikkula Riet De Rycke Eef Parthoens Saskia Lippens Savvas N. Savvides Andy Wullaert Lars Vereecke Felipe X. Pimentel-Muiños Geert van Loo Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis |
| description |
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and redundant roles in fine-tuning gut barrier homeostasis. |
| format |
article |
| author |
Karolina Slowicka Inmaculada Serramito-Gómez Emilio Boada-Romero Arne Martens Mozes Sze Ioanna Petta Hanna K. Vikkula Riet De Rycke Eef Parthoens Saskia Lippens Savvas N. Savvides Andy Wullaert Lars Vereecke Felipe X. Pimentel-Muiños Geert van Loo |
| author_facet |
Karolina Slowicka Inmaculada Serramito-Gómez Emilio Boada-Romero Arne Martens Mozes Sze Ioanna Petta Hanna K. Vikkula Riet De Rycke Eef Parthoens Saskia Lippens Savvas N. Savvides Andy Wullaert Lars Vereecke Felipe X. Pimentel-Muiños Geert van Loo |
| author_sort |
Karolina Slowicka |
| title |
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis |
| title_short |
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis |
| title_full |
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis |
| title_fullStr |
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis |
| title_full_unstemmed |
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis |
| title_sort |
physical and functional interaction between a20 and atg16l1-wd40 domain in the control of intestinal homeostasis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/66f4ba80a7fd4950b7b10906aec986dc |
| work_keys_str_mv |
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