Combination of valproate and paroxetine in mice exposed to picrotoxin

Sahar M KamalDepartment of Pharmacology, Faculty of Medicine, University of Ain-Shams, Cairo, EgyptAbstract: The frequent coexistence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with antiepileptic drugs in the management of such cases. However, i...

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Autor principal:	Kamal SM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/66f7c6e71d284ff0bcf7edacdcde6143
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spelling	oai:doaj.org-article:66f7c6e71d284ff0bcf7edacdcde61432021-12-02T01:32:22ZCombination of valproate and paroxetine in mice exposed to picrotoxin1176-91141178-2013https://doaj.org/article/66f7c6e71d284ff0bcf7edacdcde61432012-05-01T00:00:00Zhttp://www.dovepress.com/combination-of-valproate-and-paroxetine-in-mice-exposed-to-picrotoxin-a9951https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sahar M KamalDepartment of Pharmacology, Faculty of Medicine, University of Ain-Shams, Cairo, EgyptAbstract: The frequent coexistence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with antiepileptic drugs in the management of such cases. However, it is necessary to evaluate the safety of these antiepileptic/antidepressant drug combinations. The present study investigates the effect of the antidepressant paroxetine (a selective serotonin reuptake inhibitor) administered alone or in combination with the antiepileptic drug sodium valproate on chemoconvulsions induced by picrotoxin (PTX). Seizure score was recorded in vivo, and the levels of thiobarbituric acid-reactive substances and gamma aminobutyric acid (GABA) were measured in the nucleus accumbens of the tested groups of mice. The results show enhancement of seizure severity with significant reduction in GABA levels upon PTX treatment that were reversed by its combination with sodium valproate. On the other hand, paroxetine administered in combination with sodium valproate provided significant protection against PTX-induced convulsions as well as a significant increase in GABA levels in selected brain areas. These results favor their application in management of epilepsy-depression comorbidities.Keywords: valproate, paroxetine, GABA, nucleus accumbens, albino miceKamal SMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2583-2589 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kamal SM Combination of valproate and paroxetine in mice exposed to picrotoxin
description	Sahar M KamalDepartment of Pharmacology, Faculty of Medicine, University of Ain-Shams, Cairo, EgyptAbstract: The frequent coexistence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with antiepileptic drugs in the management of such cases. However, it is necessary to evaluate the safety of these antiepileptic/antidepressant drug combinations. The present study investigates the effect of the antidepressant paroxetine (a selective serotonin reuptake inhibitor) administered alone or in combination with the antiepileptic drug sodium valproate on chemoconvulsions induced by picrotoxin (PTX). Seizure score was recorded in vivo, and the levels of thiobarbituric acid-reactive substances and gamma aminobutyric acid (GABA) were measured in the nucleus accumbens of the tested groups of mice. The results show enhancement of seizure severity with significant reduction in GABA levels upon PTX treatment that were reversed by its combination with sodium valproate. On the other hand, paroxetine administered in combination with sodium valproate provided significant protection against PTX-induced convulsions as well as a significant increase in GABA levels in selected brain areas. These results favor their application in management of epilepsy-depression comorbidities.Keywords: valproate, paroxetine, GABA, nucleus accumbens, albino mice
format	article
author	Kamal SM
author_facet	Kamal SM
author_sort	Kamal SM
title	Combination of valproate and paroxetine in mice exposed to picrotoxin
title_short	Combination of valproate and paroxetine in mice exposed to picrotoxin
title_full	Combination of valproate and paroxetine in mice exposed to picrotoxin
title_fullStr	Combination of valproate and paroxetine in mice exposed to picrotoxin
title_full_unstemmed	Combination of valproate and paroxetine in mice exposed to picrotoxin
title_sort	combination of valproate and paroxetine in mice exposed to picrotoxin
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/66f7c6e71d284ff0bcf7edacdcde6143
work_keys_str_mv	AT kamalsm combinationofvalproateandparoxetineinmiceexposedtopicrotoxin
_version_	1718403020023136256

Combination of valproate and paroxetine in mice exposed to picrotoxin

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