Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults

BackgroundThe increase in diabetes worldwide is alarming. Decreased acute insulin response to intravenous glucose tolerance test (IVGTT) during first-phase insulin secretion (FPIS) is a characteristic of diabetes. However, knowledge of the insulin secretion characteristics identified by different ti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tao Yuan, Shuoning Song, Tianyi Zhao, Yanbei Duo, Shihan Wang, Junxiang Gao, Shixuan Liu, Yingyue Dong, Rui Li, Yong Fu, Weigang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	normal glucose tolerance type 2 diabetes mellitus intravenous glucose tolerance test first-phase insulin secretion insulin sensitivity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/66fdc085c99b4a16848e4f65eb422b75
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:66fdc085c99b4a16848e4f65eb422b75
record_format	dspace
spelling	oai:doaj.org-article:66fdc085c99b4a16848e4f65eb422b752021-11-17T06:47:31ZPatterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults1664-239210.3389/fendo.2021.738427https://doaj.org/article/66fdc085c99b4a16848e4f65eb422b752021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.738427/fullhttps://doaj.org/toc/1664-2392BackgroundThe increase in diabetes worldwide is alarming. Decreased acute insulin response to intravenous glucose tolerance test (IVGTT) during first-phase insulin secretion (FPIS) is a characteristic of diabetes. However, knowledge of the insulin secretion characteristics identified by different time to glucose peak in subjects with different metabolic state is sparse.AimsThis study aimed to find different patterns of FPIS in subjects with normal glucose tolerance (NGT) and analyzed the relationship between insulin secretion patterns and the risk for development of type 2 diabetes mellitus (T2DM).MethodsA total of 126 subjects were divided into three groups during a 10-min IVGTT, including NGT with time to glucose peak after 3 min (G1, n = 21), NGT with time to glucose peak at 3 min (G2, n = 95), and prediabetes or diabetes with time to glucose peak at 3 min (G3, n = 10). Glucose, insulin, and C-peptide concentrations at 0, 3, 5, 7, and 10 min during the IVGTT were tested. IVGTT-based indices were calculated to evaluate the insulin secretion and insulin sensitivity.ResultsAge, body mass index (BMI), waist-to-hip ratio, triglyceride (TG), and hemoglobin A1c (HbA1c) of subjects were gradually higher, while high-density lipoprotein cholesterol (HDL-C) was gradually lower from G1 to G3 (p for linear trend <0.05), and the differences between G1 and G2 were also statistically significant (p < 0.05). Glucose peak of most participants in G1 converged at 5 min, and the curves shape of insulin and C-peptide in G2 were the sharpest among three groups. There was no significant difference in all IVGTT-based indices between G1 and G2, but AUCIns, AUCIns/AUCGlu, and △Ins3/△Glu3 in G2 were the highest, and the p-value for linear trend of those indices among three groups were statistically significant (p < 0.05).ConclusionsTwo patterns of FPIS were in subjects with NGT, while subjects with later time to glucose peak during FPIS might be less likely to develop T2DM in the future.Tao YuanShuoning SongTianyi ZhaoYanbei DuoShihan WangJunxiang GaoShixuan LiuYingyue DongRui LiYong FuWeigang ZhaoFrontiers Media S.A.articlenormal glucose tolerancetype 2 diabetes mellitusintravenous glucose tolerance testfirst-phase insulin secretioninsulin sensitivityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	normal glucose tolerance type 2 diabetes mellitus intravenous glucose tolerance test first-phase insulin secretion insulin sensitivity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	normal glucose tolerance type 2 diabetes mellitus intravenous glucose tolerance test first-phase insulin secretion insulin sensitivity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Tao Yuan Shuoning Song Tianyi Zhao Yanbei Duo Shihan Wang Junxiang Gao Shixuan Liu Yingyue Dong Rui Li Yong Fu Weigang Zhao Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
description	BackgroundThe increase in diabetes worldwide is alarming. Decreased acute insulin response to intravenous glucose tolerance test (IVGTT) during first-phase insulin secretion (FPIS) is a characteristic of diabetes. However, knowledge of the insulin secretion characteristics identified by different time to glucose peak in subjects with different metabolic state is sparse.AimsThis study aimed to find different patterns of FPIS in subjects with normal glucose tolerance (NGT) and analyzed the relationship between insulin secretion patterns and the risk for development of type 2 diabetes mellitus (T2DM).MethodsA total of 126 subjects were divided into three groups during a 10-min IVGTT, including NGT with time to glucose peak after 3 min (G1, n = 21), NGT with time to glucose peak at 3 min (G2, n = 95), and prediabetes or diabetes with time to glucose peak at 3 min (G3, n = 10). Glucose, insulin, and C-peptide concentrations at 0, 3, 5, 7, and 10 min during the IVGTT were tested. IVGTT-based indices were calculated to evaluate the insulin secretion and insulin sensitivity.ResultsAge, body mass index (BMI), waist-to-hip ratio, triglyceride (TG), and hemoglobin A1c (HbA1c) of subjects were gradually higher, while high-density lipoprotein cholesterol (HDL-C) was gradually lower from G1 to G3 (p for linear trend <0.05), and the differences between G1 and G2 were also statistically significant (p < 0.05). Glucose peak of most participants in G1 converged at 5 min, and the curves shape of insulin and C-peptide in G2 were the sharpest among three groups. There was no significant difference in all IVGTT-based indices between G1 and G2, but AUCIns, AUCIns/AUCGlu, and △Ins3/△Glu3 in G2 were the highest, and the p-value for linear trend of those indices among three groups were statistically significant (p < 0.05).ConclusionsTwo patterns of FPIS were in subjects with NGT, while subjects with later time to glucose peak during FPIS might be less likely to develop T2DM in the future.
format	article
author	Tao Yuan Shuoning Song Tianyi Zhao Yanbei Duo Shihan Wang Junxiang Gao Shixuan Liu Yingyue Dong Rui Li Yong Fu Weigang Zhao
author_facet	Tao Yuan Shuoning Song Tianyi Zhao Yanbei Duo Shihan Wang Junxiang Gao Shixuan Liu Yingyue Dong Rui Li Yong Fu Weigang Zhao
author_sort	Tao Yuan
title	Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
title_short	Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
title_full	Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
title_fullStr	Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
title_full_unstemmed	Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
title_sort	patterns of insulin secretion during first-phase insulin secretion in normal chinese adults
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/66fdc085c99b4a16848e4f65eb422b75
work_keys_str_mv	AT taoyuan patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT shuoningsong patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT tianyizhao patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT yanbeiduo patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT shihanwang patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT junxianggao patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT shixuanliu patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT yingyuedong patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT ruili patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT yongfu patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults AT weigangzhao patternsofinsulinsecretionduringfirstphaseinsulinsecretioninnormalchineseadults
_version_	1718425863939162112

Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults

Ejemplares similares